Registration Dossier
Registration Dossier
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EC number: 269-145-7 | CAS number: 68188-19-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Test Method 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- other: LD50
- Limit test:
- no
Test material
- Reference substance name:
- Sulfonyl chlorides, C10-21-alkane
- EC Number:
- 293-741-6
- EC Name:
- Sulfonyl chlorides, C10-21-alkane
- Cas Number:
- 91082-29-0
- IUPAC Name:
- 91082-29-0
- Reference substance name:
- C10-C20 alkane sulfonyl chlorides
- IUPAC Name:
- C10-C20 alkane sulfonyl chlorides
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Total volume of vehicle was 10 mL/kg
- Doses:
- 10000, 15000 mg/kg body weight
- No. of animals per sex per dose:
- Ten male rats per dose
- Details on study design:
- The observation period, after which animals were killed, was 14 days.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Mortality:
- No mortality occurred during the full observational period
Applicant's summary and conclusion
- Conclusions:
- No mortality occurred after a single administration to male Wistar rats by oral gavage up to a dose of 15000 mg/kg bodyweight.
- Executive summary:
The acute oral toxicity of C10-21 alkane sulfonyl chloride was tested in male Wistar rats following the principles of the now deleted OECD Test Method 401 (Acute Oral Toxicity) with acceptable modifications. Single doses of the test substance were administered by oral gavage up to a maximum dose of 15000 mg/kg body weight. No mortility was observed at any of the administered doses. The LD50 of the test material (C10-21 alkane sulfonyl chloride) was > 15000 mg/kg bodyweight.
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