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EC number: 202-501-1 | CAS number: 96-34-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Skin irritation: read across: ethyl chloroacetate (OECD 404).
Eye irritation: Experimental results on methyl chloroacetate: no guideline was followed. However, the test method was similar to OECD 405.
Key value for chemical safety assessment
Additional information
Based on the results observed in the skin irritation study, strong damages of the skin in the form of redness, swelling, scabbing, cracking, hardening, sheds and burns were observed. Under the test conditions described, the substance proved to have a strong skin irritant and corrosive effect. However, the duration of exposure was 24 hours instead of 4 hours as recommended in the guidelines. The study is considered to be not reliable. There is a skin irritation study conducted on the analogue ethyl chloroacetate which has been conducted according to the recommended guideline OECD 404. Based on the results obtained in this study, the substance is classified as skin irritating.
The analogue ethyl chloroacetate which shares the same functional group with methyl chloroacetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is 0.94 -1.12 for ethyl chloroacetate and 0.63 for methyl chloroacetate,
- a high water solubility which is 20 g/l at approximately 20 ºC for ethyl chloroacetate and 51.6 g/l for methyl chloroacetate and
- similar molecular weights which are 122.55 for ethyl chloroacetate and 108.52 for methyl chloroacetate.
Furthermore, in the acute dermal toxicity studies conducted with methyl chloroacetate with rats and rabbits, no indication of necrosis is reported in the study although erythema and oedema were observed in the animals. Finally, the substance methyl chloroacetate is included in the list of harmonised classifications and labellings and it is classified as "Skin irritant Category 2".
Based on the results observed in an acute inhalation study, methyl monochloroacetate was found to be a pronounced irritant of the respiratory tract at levels of 250 -1000 ppm.
Based on the results observed in the eye irritation study, the mean scores for 24-72 h for eye irritation are 2.22, 2.17 and 2.22 for cornea opacity, conjunctiva redness and conjunctiva chemosis, respectively. However, there is no information on the reversibility of the observed damage. In this context, persistent lesions are considered those which are not fully reversible within an observation period of normally 21 days. Substances are also classified in Category 1 if they fulfil the criteria of corneal opacity ≥ 3 or iritis > 1,5 detected in a Draize eye test with rabbits, recognising that such severe lesions usually do not reverse within a 21-day observation period. In this study, at 72 hours, three animals showed corneal opacity = 3. Although there is no information on the reversibility of the damage, the substance is included in the list of harmonised classifications and labelling and it is classified as "Irreversible effects on the eyes Category 1".
Effect level: empty Endpoint conclusion: Adverse effect observed
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on the results observed in the skin irritation study conducted with the analogue ethyl chloroacetate, the results observed in the acute dermal toxicity studies conducted with the substance methyl chloroacetate and the harmonised classification included in the CLP Regulation, the substance is classified as "Skin irritant Category 2".
Based on the results observed in an acute inhalation study, methyl monochloroacetate was found to be a pronounced irritant of the respiratory tract at levels of 250 -1000 ppm. Therefore, the substance is classified as STOT SE Category 3, H335: May cause respiratory irritation.
Based on the results observed in the eye irritation study, the mean scores for 24-72 h for eye irritation are 2.22, 2.17 and 2.22 for cornea opacity, conjunctiva redness and conjunctiva chemosis, respectively. However, there is no information on the reversibility of the observed damage. Based on the harmonised classification included in the CLP Regulation, the substance is classified as "Irreversible effects on the eyes Category 1".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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