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EC number: 406-940-1 | CAS number: 126019-82-7 DP 211
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Name of test material: Irgalube 211
- Source and lot/batch number of test material: 0018757720
- Expiration date of the lot/batch: 13 Feb 2021
- Purity: 100% UVCB
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage: at room temperature
- Stability under storage conditions: guaranteed by the sponsor - Analytical monitoring:
- no
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- The test substance is liquid and poorly soluble in water. Therefore, the test
substance was dissolved in acetone for application. Aliquots of the stock solution with
required amounts of test substance for each scheduled test concentration were carefully
mixed with quartz sand portions. The organic solvent was removed by evaporation and
subsequently blended with prepared test substrate. Thereafter, the water content of the soil was adjusted to about 50% WHCmax using deionized water and was mixed once again. The test mixtures were distributed to the test units. - Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- Only adult worms (with clitellum) with a fresh weight between 300 and 600 mg were used.
The worms that were introduced into the test were bred in horse manure and had an age
from about 12 months.
Acclimatization:
Before starting the test, the worms selected were acclimatized in the test substrate in a
plastic box under test conditions through overnight under permanent light and without
feeding. For this, a plastic box was filled up with approx. 750.1 g test substrate (Dw) and
added with a sufficient number of adult worms that were sorted out from the breeding
boxes. - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 56 d
- Test temperature:
- 20.3 °C – 21.3 °C
- pH:
- 6.3 - 6.4 at start
6.7 - 6.8 at end of exposure - Moisture:
- 47.6 - 48.5 % WHCmax at start
50.7 - 58.9 % WHCmax at end of exposure - Details on test conditions:
- TEST SYSTEM
- Test container (material, size): Bellaplast 1 L plastic containers were used as test vessels. The containers consist of inert and non-toxic plastic. The test vessels have a bottom area of 11 cm × 15.5 cm and a height of 6 cm and were covered with perforated transparent lids.
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
- No. of replicates per vehicle control: 8
OTHER TEST CONDITIONS
- Photoperiod: 16h light: 8h dark
EFFECT PARAMETERS MEASURED: Reproduction was measured 56 days after application) and mortality and the body weight development of the parent animals were measured after 28 days after application.
VEHICLE CONTROL PERFORMED: yes - Nominal and measured concentrations:
- 0 (control), 0 (solvent control), 62.5, 125, 250, 500 and 1000 mg/kg Dw as nominal concentrations.
- Reference substance (positive control):
- yes
- Remarks:
- BAS 346 F (Carbendazim) was tested as reference substance in order to show the sensitivity of the test system.
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 56 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- No mortality occurred in the controls or any treatment.
- Results with reference substance (positive control):
- The reference substance BAS 346 F (Carbendazim) was tested by a non-GLP project
68E0902/00G027 (start of exposure 15 April 2019).
ECx values [mg/kg soil (dw)], reproduction by counting juvenile worms, conf. limits 95%
EC10: 0.56 LCL: 0.45 UCL: 0.71
EC50: 1.03 LCL: 0.91 UCL: 1.16
These observed effects show a high sensitivity of the test system and the derived EC50
value for reproduction toxicity by counting the number of juvenile worms is within the
expected range from the test guideline (1-5 mg/kg carbendazim/kg soil (dw)) and hence
acceptable sensitivity of the test system is assured. - Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance is not harmful to terrestrial macroorganisms.
Reference
Description of key information
NOEC(56h) >= 1000 mg/kg soil dw for reprodution of Eisenia fetida (OECD 222)
Key value for chemical safety assessment
Additional information
One study is available investigating the long-term toxicity of the test substance to terrestrial macroorganisms. The study was performed accoring to GLP and OECD guideline 222 using Eisenia fetida as test organism (BASF 2020). Concentrations between 62.5 and 1000 mg/kg soil dw were tested in artificial soil. Aceton was used as vehicle. No mortality occurred in the controls and any treatment throughout the test. No inhibition of reproduction was observed. Thus, the 56h-NOEC value is determined to be >= 1000 mg/kg soil dw based on nominal concentrations.
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