Bis(ethyl acetoacetato-O1',O3)bis(2-methylpropan-1-olato)titanium

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.1 mg/L

Assessment factor:

1 000

PNEC freshwater (intermittent releases):

1 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0.01 mg/L

Assessment factor:

10 000

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

28 mg/L

Assessment factor:

10

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.082 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0.008 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.019 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Conclusion on classification

The following reliable data is available for environmental classification of this titanate:

Acute Aquatic Toxicity:

Short-term toxicity to fish:

The 96-h LC50 (mortality) to Leuciscus idus, 275 mg/l based on nominal concentrations (read-across from ethyl acetoacetate; European Chemicals Bureau 2002)

Short term toxicity to invertebrates:

The 48-hour EC50 (immobilisation) to Daphnia magna, > 29 ethyl acetoacetate per litre and > 9.8 mg 2 -methylpropanol per litre based on the measured TWA concentrations of the hydrolysis products at loading rate of 100 mg test item per litre (OECD 202; Tobor-Kaplon M.A. 2013).

The 48-hour EC50 (immobilisation) to Daphnia magna, > 100 mg/l based on estimated test item concentrations (OECD 202; Tobor-Kaplon M.A. 2013).

Toxicity to algae:

The 72h-EC50 (growth rate) to Pseudokirchnerella subcapitata, > 13 mg ethyl acetoacetate per litre and > 4 mg 2-methylpropanol per litre; based on the measured TWA concentrations of the hydrolysis products at loading rate of 100 mg test item per litre (OECD 201; Tobor-Kaplon M.A. 2013).

The 72h-EC50 (growth rate) to Pseudokirchnerella subcapitata, > 100 mg/l based on estimated test item concentrations (OECD 201; Tobor-Kaplon M.A. 2013).

The 72h-NOEC (growth rate) to Pseudokirchnerella subcapitata, 13 mg ethyl acetoacetate per litre and 4 mg 2 -methylpropanol per litre, based on the measured TWA concentrations of the hydrolysis product at loading rate of 100 mg test item per litre (OECD 201; Tobor-Kaplon M.A. 2013).

The 72h-NOEC (growth rate) to Pseudokirchnerella subcapitata, 100 mg/l based on estimated test item concentrations (OECD 201; Tobor-Kaplon M.A. 2013).

Conclusion: No acute aquatic toxicity as the lowest of the available toxicity value is > 100 mg/l.  

Degradation:  

Abiotic degradation (hydrolysis): Hydrolytically unstable, Half-life less than 10 minutes @ 25 deg. C (OECD 111)

Main organic decomposition products are non-toxic to aquatic environment and readily biodegradable (2-methylpropanol; 72 % at 20-d biodegradation, Price et al. 1974) and the biodegradation of ethyl acetoacetate after 28-d is 66 %. After 7 days, 65 % ethyl acetoacetate was degraded and 10-day window was fulfilled (European Chemicals Bureau 2002).

The aquatic toxicity values (EC50/LC50) of the 2-methylpropanol (IBA) based on the literature are:

The 96-h LC50 (mortality) to Pimephales promelas; 1 460 mg/L (Veith et al. 1983)

The 96 h LC50 (mortality) to Pimephales promelas; 1 430 mg/l with 95 % CL of 1370-1490 mg/l (Broderius et al. 1995)

The 48-h EC50 (immobilisation) to Daphnia magna; 1 439 mg/l (95% CL 1070-1933 mg/l) (Kuehn et al. 1989)

The 24-hour EC50 (immobilisation) to Daphnia magna; 1 220 mg/l (Bringmann & Kuehn 1977)

The 48-h EC50 (immobilisation) to Daphnia magna; 1 300 mg/L with 95% CL of 1200-1400 mg/l (Elnabarawy et al. 1986)

The 48-h EC50 (immobilisation) to Daphnia pulex; 1 100 mg/L with 95% CL of 950-1200 mg/l (Elnabarawy et al. 1986)

The 24-h EC50 (immobilisation) to Daphnia magna; 1 250 mg/l and 21-d NOEC (reproduction); 4 mg/l (Kuhn et al.1989)

The 48-h EC50 (growth rate) to Desmodesmus subspicatus; 2 300 mg/L (Kuhn & Pattard 1990)

The 7d toxicity threshold to Scenedesmus quadricauda; 350 mg/l (Bringmann &Kuhn 1980)

For ethyl acetoacetate the aquatic toxicity values in the literature are the following:

The 48-h LC50 (mortality) to Leuciscus idus; 275 -575 mg/l (European Chemicals Bureau 2002)

The 24-h EC50 (immobilisation) to Daphnia magna; 790 to 800 mg/l. LC100 values varied between 1250 to 1136 mg/l, respectively (European Chemicals Bureau 2002).

The 72-h EC50 (growth rate) to Desmodesmus subspicatus; > 500 mg/l (European Chemicals Bureau 2002).

Conclusion: rapidly degradable.  

Bioaccumulation:

Log Kow for the main degradation products (2-methylpropanol; 0.76 and ethyl acetoacetate; 0.25). Not possible to determine for the target substance because of rapid hydrolysis.  

Conclusion: No chronic aquatic toxicity as the lowest available toxicity value (72 -h NOEC for algae) for the substance itself is 100 mg/l and the lowest 21-d NOEC for the degradation product (2 -methylpropanol) is 4 mg/l, substance is rapidly degradable, and the degradation products have low potential for bioconcentration and bioaccumulation.  

Environmental classification:

In accordance with EC Regulation 1272/2008 (CLP):

Not classified as hazardous

In accordance with DSD (Directive 67/548/EEC):

Not classified as hazardous