Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-427-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Guideline study with no deviations and compliant with GLP. The octanol-water partition coefficient (Pow) for Modified Small Vinyl Ester was determined using the HPLC method at neutral pH and at pH = 1.5. Due to its complex composition, Pow was determined only for the two major constituents (bisGMA, ca. 57.5%; and monomaleic bisGMA, ca. 14.5%). At neutral pH logPow for monomaleic bisGMA and bisGMA was determined to <0.3 and 4.1, respectively; at pH = 1.5 logPow was determined to 4.3 for both constituents.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.3
- at the temperature of:
- 25 °C
Additional information
The octanol-water partition coefficient of Modified Small Vinyl Ester was determined in a guideline study using the HPLC method at neutral pH and at pH = 1.5. Due to complex composition of Modified Small Vinyl Ester, Pow was determined only for the two major constituents (bisGMA, ca. 57.5%; and monomaleic bisGMA, ca. 14.5%). In addition to the guideline study, the octanol-water partion coefficients of the two main constituents of Modified Small Vinyl Ester (bisGMA and monomaleic bisGMA) were calculated using the Rekker method.
The HPLC chromatograms showed two major peaks and a number of small peaks. The major peaks were allocated to the main constituents of Modified Small Vinyl Ester (bisGMA and monomaleic bisGMA). The small peaks were allocated to other constituents and to the oligomeric substances composing the third constituent. At neutral pH logPow for monomaleic bisGMA and bisGMA was determined to <0.3 and 4.1, respectively; at pH = 1.5 logPow was determined to 4.3 for both constituents. The calculated logPow's were 6.8 and 7.9 for monomaleic bisGMA and bisGMA, respectively.
Based on these experimental data, logPow for Modified Small Vinyl Ester is set to 4.3 at neutral pH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.