Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-736-1 | CAS number: 865-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Based on the available data on the hydrolysis products potassium hydroxide (CAS 1310-58-3) and methanol (CAS 67-56-1), there is no concern for carcinogenicity of potassium methanolate.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on data from the hydrolysis products methanol and potassium hydroxide, there is no indication or evidence leading to concern for a carcinogenic potential of potassium methanolate.
Additional information
No data are available on carcinogenicity of potassium methanolate. The abiotic hydrolysis of potassium methanolate under aqueous conditions results in the formation of methanol and potassium hydroxide. The latter dissociates into the corresponding cations (K+) and anions (OH-). Therefore, data of the hydrolysis products were taken into account for hazard assessment of potassium methanolate.
According to the OECD SIDS of potassium hydroxide (OECD, 2002), no valid carcinogenicity studies with animals are available. It was concluded that there is no evidence of KOH to be carcinogenic in exposure situations that are relevant for humans (OECD, 2002; OECD 2006). Only at repeated exposure to highly irritant concentrations leading to a prolonged inflammatory response local carcinogenicity due to a non-genotoxic mechanism by direct hyperplasia as a consequence of severe tissue damage could occur, as described in an old mouse skin painting study (25 to 46 weeks of exposure) with irritant concentrations of KOH (3 - 6 %) (RL 3 due to methodological deficiencies according to OECD (2002), therefore not included in IUCLID). For the hydrolysis product methanol, there are studies available, which showed carcinogenicity in mice and rats via the oral or inhalation route (please refer to the endpoint summary of methanol for details). However, the studies have been challenged and it was concluded that methanol is not likely to be carcinogenic in humans.
In conclusion, based on the available data there is no concern for carcinogenicity of potassium methanolate. In addition, the available data on genotoxicity indicate that potassium methanolate and its hydrolysis products are not genotoxic.
References not included as study summaries in IUCLID:
OECD SIDS Initial Assessment Report for SIAM 13 (2002): Potassium Hydroxide (CAS No: 1310-58-3).
OECD SIDS Initial Assessment Report for SIAM 22 (2006): Category of Methanolates: Sodium Methanolate, Potassium Methanolate (CAS No: Sodium Methanolate: 124-41-4; Potassium Methanolate: 865-33-8).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.