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EC number: 231-659-4 | CAS number: 7681-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The 24 hours LD50 to rat by oral is 3118 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 118 mg/kg bw
Additional information
Since the granular size of the crystals of potassium iodide is evidently bigger than 100 μm, the VP of potassium iodide is low as well; the inhalation is unlikely exposure route for human.
From research (Louk A. R. M. Pechtold et al., 2001), in order to study at the ultrastructural level which part of the skin is associated with percutaneous iodide transport by passive diffusion, the iodide (KI solution) was applied to the frozen skin of human. Then by the transmission electron microscopy (TEM) and X-ray microanalysis (XRMA), the distribution of iodide in each layer of skin after passive diffusion can be well investigated. It concluded that the iodide can penetrate into stratum corneum (SC), but little can enter viable epidermis. Based on this the absorption of iodide by dermal route is also negligible. Therefore the key value of acute toxicity is only available by oral route.
The most relevant study on vertebrates by oral route is a company study (A. Hausner, G. Weise, and A. Hofmann, 1980). In the test the effects of iodide were studied in male and female Wistar rats. 10 male and 10 female in each dose and control groups were administrated with potassium iodide for 14 days at dose of 0 (control), 2000, 2500, 2800 3200, 3600, and 4000 mg/kg body weight mg/kg bw respectively. The key value of LD50 was calculated by Probit-analysis (Fink und Hund 1965).
It shows the 24 hour and 7-14 days of LD50 to rats (male/female) was respectively 3118 and 2779 mg/kg bw under test conditions.
The human data is from an accident, in which a suicide was attempted; an adult male survived the ingestion of 15 g of iodine as a potassium iodide solution (Tresch et al., 1974). From the human data, the default body weight (70 kg) was used, and the 100% absorption was assumed, by which the LD50 for human in this accident is over 214 mg/kg bw, which is well supported the LD50 data from the company study report.
Therefore the key value which is used in the hazard classification and chemical safety assessment is 3118 mg/kg bw.
Justification for classification or non-classification
The LD50 oral is 3118 mg/kg bw, which is definitely above 2000 (mg/kg bodyweight) so the iodide should not be classified under any categories of acute toxicity in the Regulation (EC) No. 1272/2008, and the Directive 67/548/EEC.
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