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EC number: 629-721-4 | CAS number: 308062-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
There are no toxicokinetic studies available with Amines, di-C16-18 (even-numbered) alkyl, CAS No. 308062-60-4, (DASA). The toxicokinetic fate has therefore been derived based on the physicochemical properties of the substance and from data on didecyldimethylammonium chloride, CAS No.7173-51-5 (DDAC), which is structurally similar to DASA. Overall, DASA is expected to be absorbed in the gastrointestinal tract only to a very limited extent and with corresponding poor tissue distribution. The most likely metabolic pathway and excretion data from DDAC supports a rapid elimination of DASA. Accordingly, bioaccumulation is not expected to occur.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
There are no toxicokinetic studies available with Amines, di-C16-18 (even-numbered) alkyl, CAS No. 308062 -60 -4 (DASA). Determination of toxicokinetic parameters are therefore based on the available physicochemical data for DASA and on read-across from didecyldimethylammonium chloride, CAS No.7173-51-5 (DDAC) for which a toxicokinetic study performed according to OECD guideline and under GLP conditions is available. A read-across from DDAC to DASA is considered justified as the common carbon chains will most likely be the main factor in determining the toxicokinetic parameters. Furthermore, as DASA is a weak base it will be protonated under the acidic conditions of the stomach. This will result in a net positive charge on the amine group similar to DDAC. Accordingly, these molecules are structurally similar and will have the same properties under relevant physiological conditions.
Absorption
Studies with DDAC demonstrated low absorption, <5% of administered dose, from the gastrointestinal tract. It can be expected that DASA will show similar absorption, or even less, as the carbon chains of DASA are significantly longer (C16-18) relative to DDAC (C10). The limited gastrointestinal absorption is also supported by the physicochemical data on DASA. With a molecular mass of greater than 500 and a calculated log Kowof 16.5, gastrointestinal absorption is expected to be low (Lipinski’s rule of 5). Absorption from lung is not considered relevant as the vapour pressure of DASA is low and no formation of aerosols is expected during manufacture and the use lifecycle of the substance.
Distribution
A wide distribution of DASA is not expected based on the studies with DDAC. The majority of DDAC is associated with intestines and with only very low levels found in central organs.
Excretion
Rapid excretion of DDAC has been observed, primarily via the feces. This is also expected for DASA. Bioaccumulation is not considered likely based on these findings.
Metabolism
The primary metabolic pathway for DASA is expected to be oxidation of the carbon chain as was observed with DDAC. Glucuronide and sulphate conjugation were also observed but only to a limited extent. The most likely metabolic transformations for DASA will all result in metabolites with increased solubility. This will further increase excretion and supports that bioaccumulation of DASA is unlikely.
Although no studies are available with DASA, the toxicokinetic fate has been derived based on the physicochemical properties of the substance and from data on DDAC, which is structurally similar to DASA. Overall, DASA is expected to be absorbed in the gastrointestinal tract only to a very limited extent and with corresponding poor tissue distribution. The most likely metabolic pathway and excretion data from DDAC supports a rapid elimination of DASA. Accordingly, bioaccumulation is not expected to occur.
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