Registration Dossier
Registration Dossier
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EC number: 214-730-4 | CAS number: 1191-16-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable data, report with limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Determination of dermal LD50 of test substance in rabbits
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methyl-2-butenyl acetate
- EC Number:
- 214-730-4
- EC Name:
- 3-methyl-2-butenyl acetate
- Cas Number:
- 1191-16-8
- Molecular formula:
- C7H12O2
- IUPAC Name:
- 3-methylbut-2-en-1-yl acetate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Prenyl Acetate
- Sample marking: 77-400
No additional details provided
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Frequency of observations and weighing: not specified; the animals were observed for mortality and/or toxic signs.
- Necropsy of survivors performed: yes
No further details provided - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality observed
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: Toxic signs included diarrhea.
- Gross pathology:
- Necropsy findings included a brown exudate in the anogenital area, and changes in intestines (red areas), liver (dark), lungs (dark areas), kidneys (dark, mottled), and spleen (dark) in single animals.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
