Registration Dossier
Registration Dossier
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EC number: 201-222-2 | CAS number: 79-74-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is not performed under GLP conditions, used methods and results are preliminary documented.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were exposed to 2000, 3160, 5010, 7940 mg/kg bw Santovar A in corn oil during 24 hours and were observed for 14 days.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Details on test material:
- - Name of test material (as cited in study report): Santovar A
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- corn oil
- Duration of exposure:
- 24 hours
- Doses:
- 2000, 3160, 5010, 7940 mg/kg bw Santovar A
- No. of animals per sex per dose:
- 1 or 2 at highest dose
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Mortality:
- Yes, at 5010 and 7940 mg/kg bw after 4 and 5 days, resp.
- Clinical signs:
- other: Reduced appetite and activity, increasing weakness, collapse, and death.
- Gross pathology:
- Lung and liver hyperemia, enlarged gall bladder, and gastrointestinal inflammation.
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Executive summary:
- A study in rabbits suggested that Santovar was slightly toxic, a dermal LD50 of > 3160 mg/kg bw was reported. The study was not performed according to the general guidelines for dermal toxicity under GLP conditions and was very poorly documented. Therefore, the information may be considered reliable with major restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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