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EC number: 215-252-9 | CAS number: 1315-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For tin disulfide an algal study is available. This study demonstrated that the tin sulfide has no toxic effects at the limit of water solubility, i.e., at 0.67 µg/L. The other aquatic endpoints were covered using data from tin sulfide which has an almost identical water solubility, i.e., 0.6 µg/L. The algal study was used as bridging study since the WHO concluded in their report that alge are the most sensitive group. Furthermore, the WHO concluded that Sn II is more toxic than Sn IV. Hence, read across from tin sulfide (Sn II) to tin disulfide (Sn IV) was considered justified.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- no
- Remarks:
- The test was performed in China
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 265 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Immobilization
- Remarks on result:
- other:
- Remarks:
- Based the analysis of non-filtered samples
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: none
- Other adverse effects control: none
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values:
Tin sulfide is almost insoluble in water (water solubility 0.6 µg/L). The LOD in the present study was 1 µg/L and hence the concentration in the medium filtered for analysis was < LOD. In the medium used for exposure of the daphnids, i.e., prior filtration, a concentration of 265 µg/L was measured. This indicates that some particulate matter must have been present in the medium used for the exposure of the daphnids, This concentration was stable throughout the exposure. Since no adverse effects in the exposed daphnids, it can be concluded that the particulate material ad no adverse effects on teh daphnids.
- Effect concentrations exceeding solubility of substance in test medium: No adverse effects were observed when the daphnids were exposed to medium which contained some undissolved material. - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Relevant effect levels:
Acute Immobilisation of Potassium Dichromate on Daphnia magna
Nominal Con. (mg/L) Initial Number of Daphnids Number of Immobilised Daphnids
6 h 12 h 18 h 24 h
0 5 0 0 0 0
5 0 0 0 0
5 0 0 0 0
5 0 0 0 0
0.32 5 0 0 0 0
5 0 0 0 0
5 0 0 0 0
5 0 0 0 0
0.56 5 0 0 0 0
5 0 0 0 0
5 0 0 0 0
5 0 0 0 0
1.0 5 0 0 0 1
5 0 0 1 2
5 0 0 1 2
5 0 0 2 2
1.8 5 3 3 4 5
5 2 2 4 5
5 4 4 5 5
5 5 5 5 5
3.2 5 5 5 5 5
5 5 5 5 5
5 5 5 5 5
5 5 5 5 5
- ECx:
EC50 of the reference test at differnt timepoints
12 h 18 h 24 h
EC50 (mg/L) 1.60 1.27 1.09
95% confidence limit (mg/L):1.51~1.68 1.19~1.34 1.03~1.16 - Reported statistics and error estimates:
- not relevant since no adverse effects observed.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Tin disulfide has no acute toxicity to daphnids under the tested conditions.
- Executive summary:
The acute toxicity of tin sulfide to Daphnia magna was determined according to OECD 202 (2004). In a range-finding test 5 daphnids per treatment (no replicates) were exposed to nominal concentrations of 1.0, 10.0 and 100 mg test substance/L WAFs. No immobilization was observed. In the limit test 4 replicates with 5 daphnids per replicate each were tested at 100 mg/L WAF. A blank control was set up in parallel. After 48 h-test period all daphnids in control group and treated group were alive and appeared normal . A reference test with K2Cr2O7 under same conditions resulted in a 24h-LC50 of 1.27 mg/L. All validity criteria were fulfilled. Under valid static test conditions the 48 h -EL50 of tin sulfide to Daphnia magna is greater than the nominal tested concentration of 100 mg/L WAF and greater than the measured concentraion of 265 µg/L, which is greater than the water solubility of 0.6 µg/L. Therefore, it can be concluded that tin sulfide has no acute toxicity to Daphnia magna.
The results are considered relevant for tin disulfide since both substances have the same metal moiety and have similar physico-chemical properties, e.g., they are almost insoluble in water. Further evidence is provided in the read across justification.
Reference
Acute Immobilisation of Test Substance on Daphnia magna during the Limit Test
Nominal Con. (mg/L)
|
Initial Number of Daphnids |
24 h |
48 h |
||
Number of Immobilised Daphnids |
ImmobilisationRate (%) |
Number of Immobilised Daphnids |
Immobilisation Rate (%) |
||
Blank control
|
5 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
|||
5 |
0 |
0 |
|||
5 |
0 |
0 |
|||
100(WAFs)
|
5 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
|||
5 |
0 |
0 |
|||
5 |
0 |
0 |
|||
EC50(mg/L, based on the nominal concentration) |
>100(WAFs) |
>100(WAFs) |
Visual Observations during the Limit Test
Nominal Concentration (mg/L) |
Visual Observations |
|
24 h |
48 h |
|
Blank control |
5 NB① |
5 NB |
5 NB |
5 NB |
|
5 NB |
5 NB |
|
5 NB |
5 NB |
|
100 (WAFs) |
5 NB |
5 NB |
5 NB |
5 NB |
|
5 NB |
5 NB |
|
5 NB |
5 NB |
①NB: Normal behaviours
Analysis Results of the Test Solution in the Limit Test
Nominal Concentration (mg/L) |
Measured Concentration (μg/L) |
Measured Concentration/0h measured Concentration |
|||
0 h |
24 h |
48 h |
Mean |
||
100 (WAFs) |
272 |
259 |
263 |
265 |
97.4% |
The
results are considered relevant for tin disulfide since both substances
have the same metal moiety and have similar physico-chemical properties,
e.g., they are almost insoluble in water. Further evidence is provided
in the read across justification.
Description of key information
The test was perfomed on the read-across substance tin sulfide but is considered relevant for tin disulfide as well. Tin disulfide is not toxic to daphnids up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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