Registration Dossier
Registration Dossier
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EC number: 206-532-1 | CAS number: 353-42-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
BASF (1965) reported an acute oral LD50 value of ca. 496 mg/kg (= ca. 400 mm3/kg) for male and female rats. Here, dimethyl ether boron trifluoride was administered in doses of 25, 200, 250, 320, 400, 500, 640 and 800 mm3/kg. In the three lowest dose levels no animals died after 7 days; 400 mm3: 6/10 after 7 days, 500 mm3: 7/10 after 14 days, 640 mm3: 9/10 after 14 days, 800 mm3: all animals died within 24 hours. Clinical signs reported were apathy, ventral or lateral position, convulsions, dyspnoea.
Spiegl (1953) reported an acute inhalation test where the LC 50 lied between 2.58 mg/L/14 h and 12.1 mg/L/3.5 h. All animals died after exposure to 16.1 mg/L/9.5 h and higher.
Rusch et al. (1986) reported an acute inhalation LC50 value for boron trifluoride dihydrate (CAS: 13319 -75 -0) of 1210 mg/m3/4 h. Male and female Fischer-344 rats were used for this whole-body inhalation experiment. Concentrations used were 1.01, 1.22, 13.2 and 1.54 mg/l. Deaths occurred in all exposure groups (9/10 at 1.54 mg/l, 8/10 at 1.32 mg/l, 2/10 at 1.22 mg/l). Clinical signs elicited by the exposures included dry and moist rales, gasping, excessive oral and nasal discharge and lacrimation, indicative respiratory distress and irritation. Recovery was apparent for the rats surviving beyond 6 days post-exposure.
In an inhalation hazard test (BASF, 1965) male and female rats were exposed with a vapour concentration at 20°C of 10.5 mg/l for 10 or 30 minutes. No animal died at 10-min exposure; 6 of 12 animals died after 30-min exposure. Clinical signs reported were severe irritating of the mucosa and breathlessness.
No data are available regarding acute dermal toxicity.
Justification for classification or non-classification
Due to the corrosivity of dimethyl ether boron trifluoride, testing regarding acute toxicity is not meaningful.
The structure-related test compound boron trifluoride is classified with T+ and R26 (EU) and Acute Tox. Cat. 2, H 330 (GHS). For test compound boron trifluoride dihydrate proposal for classification is Acute Tox. Cat. 4, H332 (GHS) and Xn, R20 (EU).
Classification proposal based on the available data of BF3 dihydrate and BF3 dimethyl-ether: according to EU = Xn; R20/22 - according to GHS: Acute Tox. 4 (H302 and H332).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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