Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 402-170-5 | CAS number: 106359-91-5 C.I. REACTIVE YELLOW 174; GIALLO REATTIVO 174; JAUNE REACTIF 174; REAKTIV GELB 174
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 February 1987 to 06 February 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Holding : in dechlorinated tap water Test : in artifical water Temperature: lower temperature Limit Test : 1 concentration tested
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: Op. 1/86, Vers. 10/86 - Analytical monitoring:
- yes
- Details on sampling:
- Water samples were taken from the bath at the beginning and at the end of the experiment.
- Vehicle:
- no
- Details on test solutions:
- The test substance was dissolved in 200 mL water, which were slowly added to the fish tank.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Test organism Zebrafish (Brachidanio rerio)
- Weight: 0.19 g
- Length: 25.9 mm
- Age: 5 months
- Acclimation: 12 days in dechlorinated tap water
- Supplier: West Aquarium, Bad Lauterberg, BRD - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 100 mg/L (as CaCO3)
- Test temperature:
- 21.9 - 22.9 °C
- pH:
- 7.6 to 8.3
- Nominal and measured concentrations:
- Nominal: 1000 mg/L
Analytical: at start: 996.6; at end 1050.4 mg/L - Details on test conditions:
- - Vessels: 5 liter glass aquaria
- Volume: 2.9 liter Test concentration: (3.0 liter minus 2x 0.05 liter for analytical control)
- Number of fish: 10 fish per concentration and water control
- Feeding: none
- Aeration: slowly aerated
- Lightening: 12 hours light / 12 hours darkness (yellow light TL 16/20 W)
In a pretest carried out at 10, 30, 100, 200 and 1000 ppm the LC50 was determined to be >1000 ppm. Therefore, the test concentration in the final (limit) test was chosen as 1000 ppm. A control was carried out with water (blank control). - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- At the test concentrations used - 1000 ppm - (1000 mg/L), no mortalities were evident. An LC50 could therefore not be calculated.
- Sublethal observations / clinical signs:
No abnormal responses and mortalities of the fish were observed.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 FAT 40224/C is >1000 mg/L to zebrafish.
- Executive summary:
Acute toxicity to fish of the test substance was determined in a GLP-compliant study performed according to the OECD guideline 203. Ten zebrafish per dose were placed in a slowly aerated static system and exposed to 1000 mg/L of test substance for 96 hours. Water samples were taken from the fish tank at the beginning and at the end of the experiment to determine concentrations of the test substance present. No effects and mortalities were seen at the tested concentration, therefore the LC50 of FAT 40224/C was >1000 mg/L.
Reference
Description of key information
Acute toxicity to fish of the test substance was determined in a GLP-compliant study performed according to the OECD guideline 203. Ten zebrafish per dose were placed in a slowly aerated static system and exposed to 1000 mg/L of test substance for 96 hours. Water samples were taken from the fish tank at the beginning and at the end of the experiment to determine concentrations of the test substance present. No effects and mortalities were seen at the tested concentration, therefore the LC50 of FAT 40224/C was >1000 mg/L. The test substance is considered non-toxic to the test species.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.