Registration Dossier
Registration Dossier
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EC number: 203-157-5 | CAS number: 103-90-2
Endpoint summary
Administrative data
Description of key information
Phototransformation in air
The atmospheric oxidation half-life of Paracetamol was estimated using the AOPWIN model. It was estimated that the substance is not persistent in air medium as the half-life period of Paracetamol in air is only 0.92 days (22.08 hrs.) which is not exceeding the criteria of >2 days. The photo transformation rate is 1.8 x 10-11 cm3/molecule/sec. This indicates that Paracetamol will react at a moderate rate (22.08 hrs.) with hydroxyl radicals. The fraction of the chemical that is sorbed to organic particles in the air may be resistant to atmospheric oxidation.
Hydrolysis
According to Annex VIII, column 2 of the REACH regulation a study on hydrolysis as a function of pH ‘does not need to be conducted as the substance Paracetamol is found to be readily biodegradable, therefore this study was considered for waiver.
Phototransformation in water
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Phototransformation in soil
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Additional information
Phototransformation in air
The atmospheric oxidation half-life of Paracetamol was estimated using the AOPWIN model. It was estimated that the substance is not persistent in air medium as the half-life period of Paracetamol in air is only 0.92 days (22.08 hrs.) which is not exceeding the criteria of >2 days. The photo transformation rate is 1.8 x 10-11 cm3/molecule/sec. This indicates that Paracetamol will react at a moderate rate (22.08 hrs.) with hydroxyl radicals. The fraction of the chemical that is sorbed to organic particles in the air may be resistant to atmospheric oxidation.
OVERALL OH Rate Constant =1.8E-11cm3/molecule-sec.
Media |
Half-Life |
Percent in |
Air |
0.92 days |
0 % |
Hydrolysis
According to Annex VIII, column 2 of the REACH regulation a study on hydrolysis as a function of pH ‘does not need to be conducted as the substance Paracetamol is found to be readily biodegradable, therefore this study was considered for waiver.
Phototransformation in water
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Phototransformation in soil
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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