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EC number: 201-861-7 | CAS number: 88-85-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No guideline followed. Atypical species of animal used.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity, Uptake, and Elimination of the Herbicides Alachlor and Dinoseb in Freshwater Fish
- Author:
- Call. D.J, et al
- Year:
- 1 984
- Bibliographic source:
- J. Environ. Qual., Vol 13, no. , 1984 pp. 493 - 498
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- in vivo metabolism study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dinoseb
- EC Number:
- 201-861-7
- EC Name:
- Dinoseb
- Cas Number:
- 88-85-7
- Molecular formula:
- C10H12N2O5
- IUPAC Name:
- dinoseb
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- other: fish
- Strain:
- other: Pimephales promelas & Salmo gairdneri
- Sex:
- not specified
Results and discussion
Any other information on results incl. tables
Dinoseb was readily eliminated by trout as both parent compound and as metabolites. Ninety percent of the herbicide injected into trout was recovered in the water within 24 h, of which 50% appeared to be parent compound by TLC. At least two polar metabolites and one or two metabolites less polar than dinoseb were present in the water. A similar metabolite profile was observed in bile, except that no parent compound was present. Insufficient quantities of metabolites were available for generation of mass spectra and GC/MS characterization. Mammalian studies have shown that dinoseb is readily metabolized.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: low bioaccumulation potential based on study results
Dinoseb is not highly bioconcentrated in fish tissue, and small amounts that may accumulate are readily eliminated when the exposure ends. - Executive summary:
In a series of studies investigating the acute toxicity, effects to early-life stages as well as uptake and elimination of dinoseb, rainbow trout weighing 100 to 150 g were injected with 37 kBq of 14C-labelled herbicide after exposure for 4 to 5 days to low levels of unlabelled compound. Fish were sacrificed after 24 hours.
Dinoseb was readily eliminated by trout as both the parent compound and as metabolites. Ninety per cent of the herbicide injected into trout was recovered in the water within 24 hrs, of which 50% appeared to be parent compound by TLC. At least two polar metabolites and one or two metabolites less polar than dinoseb were present in the water. A similar metabolite profile was observed in bile, except that no parent compound was present. Insufficient quantities of metabolites were available for generation of mass spectra and GC/MS characterization.
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