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Diss Factsheets
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EC number: 220-290-4 | CAS number: 2702-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26th Sep 1991 - 10th Oct 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation Document is incomplete, but basic data can be derived.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- , document is incomplete, but basic data can be derived.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 2,4-dichlorophenoxyacetate
- EC Number:
- 220-290-4
- EC Name:
- Sodium 2,4-dichlorophenoxyacetate
- Cas Number:
- 2702-72-9
- Molecular formula:
- C8H6Cl2O3.Na
- IUPAC Name:
- sodium 2-(2,4-dichlorophenoxy)acetate
- Details on test material:
- - Name of test material (as cited in study report): Pielik 85 SP; 2,4-D sodium salt
- Physical state: white powder with intense smell
- Analytical purity: 94%
- Impurities (identity and concentrations): Chlorphenols expressed as 2,4-D Chlorphenol (0.3%); Substances insoluble in water (0.01%)
- Purity test date: 11th July 1991 (Certificate No. 1046/PK 91)
- Melting temperature of the 2,4-D acid: 139°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Medical School, Department of Toxicology, Poznan
- Age at study initiation: 2.5 months (mean)
- Weight at study initiation: 279 g for males (mean), 216 g for females (mean)
- Housing: plastic metal cage (35 x 30 x 20 cm3), 5 animals of the same sex per cage
- Diet: "Murigran" ad libitum
- Water: ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2°C
- Humidity (%): 40 - 80%
- Photoperiod (hrs dark / hrs light): 12 hour light cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- not reported
- Doses:
- 364, 473, 615 and 800 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 552 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Three male and one female animal of the highest dose group died on day 1 after application, the other animals of this dose group died on day two, respectively. In the group receiving 615 mg/kg bw, three male and one female animal died on day 3, treatment with 473 mg/kg bw led to the death of one female rat on day 3 and to the death of one male and one female rat on day 4.
- Clinical signs:
- other: The animals in the highest dose group were dejected and less active, starting shortly after the application of the test substance until death. Their hair was bristled. In the lower dose groups no toxic signs were observed except for animals that died. Sho
- Gross pathology:
- Hyperemia was found in the internal organs of the rats that died during the observation period. In addition, in 2 rats at 615 mg/kg bw softening in the liver was noticed. In the surviving rats megalosplenia was observed.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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