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Diss Factsheets
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EC number: 206-764-3 | CAS number: 373-44-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BASF-Test
- Principles of method if other than guideline:
- The fur of 2 rabbits was clipped and an 80% solution of the substance in water was applicated using a soaked test patch (2.5 x 2.5 cm). The patch was applicated onto the back of the animals. After an occlusive exposure period of 1, 5 and 15 minutes as well as 20 hours the application area was washed with Lutrol/water (1:1). Furthermore the ears were wrapped for 20 hours with a patch soaked with a 80% solution of the substance in water. Skin effects were documentated 24 hours and 8 days after the removal of the test patches.
- GLP compliance:
- no
Test material
- Reference substance name:
- Octamethylenediamine
- EC Number:
- 206-764-3
- EC Name:
- Octamethylenediamine
- Cas Number:
- 373-44-4
- Molecular formula:
- C8H20N2
- IUPAC Name:
- octane-1,8-diamine
- Details on test material:
- - Name of test material (as cited in study report): Oktamethylendiamin
- Physical state: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- Concentration: 80 %
- Duration of treatment / exposure:
- skin of the back: 1, 5 and 15 minutes, 20 hours
ear: 20 hours - Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol/water (1/1)
- Time after start of exposure: 1, 5 and 15 minutes, 20 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Necrosis score
- Basis:
- mean
- Time point:
- other: 1 minute exposure, reading after 24 hours
- Score:
- 1
- Reversibility:
- not reversible
- Remarks on result:
- other: severe irritation, marked erythema and slight edema 24 hours after an exposure of 1 minute
- Irritation parameter:
- other: Necrosis score
- Basis:
- mean
- Time point:
- other: 1 minute exposure, reading after 8 days
- Score:
- 2
- Reversibility:
- other: symptoms on the last day of the study
- Remarks on result:
- other: marked necrosis and erythema as well as slight edema 8 days after an exposure of 1 minute
- Irritation parameter:
- other: Necrosis score
- Basis:
- mean
- Time point:
- other: 5 minutes exposure, reading after 24 hours
- Score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other: marked necrosis 24 hours after an exposure of 5 minutes
- Irritation parameter:
- other: Necrosis score
- Basis:
- mean
- Time point:
- other: 5 minutes exposure, reading after 8 days
- Score:
- 2
- Reversibility:
- other: symptoms on the last day of the study
- Remarks on result:
- other: marked necrosis 8 days after an exposure of 5 minutes
- Irritation parameter:
- other: Necrosis score
- Basis:
- mean
- Time point:
- other: 15 minutes exposure, reading after 24 hours
- Score:
- >= 3
- Reversibility:
- not reversible
- Remarks on result:
- other: severe necrosis 24 hours after an exposure of 15 minutes
- Irritation parameter:
- other: Necrosis score
- Basis:
- mean
- Time point:
- other: 15 minutes exposure, reading after 8 days
- Score:
- >= 3
- Reversibility:
- other: symptoms on the last day of the study
- Remarks on result:
- other: severe necrosis 8 days after an exposure of 15 minutes
Any other information on results incl. tables
The fur of 2 rabbits was clipped and an 80% solution of the substance in water was applicated using a soaked test patch (2.5 x 2.5 cm). The patch was applicated onto the back of the animals. After an occlusive exposure period of 1, 5 and 15 minutes as well as 20 hours the application area was washed with Lutrol/water (1:1). Furthermore the ears were wrapped for 20 hours with a patch soaked with a 80% solution of the substance in water. Skin effects were documentated 24 hours and 8 days after the removal of the test patches.
The severity of substance induced edema, necroses and erythema was quantified for each time point using the following values:
Grading according to BASF-Test for necrosis (N), edema (Ö) and redness (R) |
Description |
Grading according to OECD 404 |
Ø |
no symptom |
0 |
(+) |
questionable |
0 |
+ |
slight |
1 |
++ |
marked |
2 |
+++ |
severe |
≥3 |
N+ is interpreted as sign of severe irritation while N++ or N+++ represents a full thickness necrosis.
The followign results were reported:
Time of exposure |
Symptoms after 24 hours |
Symptoms after 8 days |
1 minute |
N+/R++/Ö+ |
N++/R++/Ö+ |
5 minutes |
N++ (edge: R+ Ö+) |
N++ (edge: R++) |
15 minutes |
N+++ (edge: R++ Ö+) |
N+++ (surrounding N+) |
20 hours |
N+++ (edge: R++ Ö++) |
N+++ |
20 hours (ear) |
N+++ |
mummification |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- Classification: corrosive (causes burns)
- Executive summary:
The test substance caused full thickness necrosis 24 hours after an occlusive exposure of 5 and 15 minutes which was not reversible within 8 days. Furthermore the occlusive exposure of 1 minute caused slight necrosis and edema as well as marked erythema after 24 hours which were not reversible within 8 days while the necrosis aggravated to a marked one after 8 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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