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Diss Factsheets
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EC number: 204-642-4 | CAS number: 123-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: pre-GLP and pre-guideline study. Missing particle size and animal mortality statistics.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicity of Allyl Alcohol. I. Acute and Chronic Toxicity
- Author:
- Dunlap MK, Kodama JK, Wellington JS, Anderson HH, Hine CH
- Year:
- 1 958
- Bibliographic source:
- AMA Archives of Industrial Health, 18: 303-311
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single Vapor Exposure: Six male rats were exposed for one, four or eight hours to concentrations ranging from 40 to 23000 ppm. The nominal concentrations were calculated by the standard gas concentration formula of Jacobs and were also checked by chemical analysis. Glass bottles of 1 liter capacity containing distilled water were connected with the sampling port of the chamber, and the vapour drawn through the water by suction. To this aqueous sample was added 0.01 N bromine in acetic acid, in the presence of mercuric acetate catalyst. The excess bromine was reduced by iodide and the iodine titrated with 0.01 N thiosulfate according to the method of Reid and Beddard.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Allyl alcohol
- EC Number:
- 203-470-7
- EC Name:
- Allyl alcohol
- Cas Number:
- 107-18-6
- IUPAC Name:
- prop-2-en-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Allyl alcohol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 100 - 200 g
- Fasting period before study: no data
- Housing: in groups of five or six
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: no data
- Exposure chamber volume: 19.5 liters in capacity
- Method of holding animals in test chamber:
- Source and rate of air: air flow from 8.6 to 12.9 L/min, depending on the concentration of allyl alcohol desired
- Method of conditioning air: no data
- System of generating particulates/aerosols: a modified version of the motor-driven syringe assembly described by Carpenter and his associates delivered allyl alcohol from 10 mL Luer-Lok syringe into the chamber through an evaporation through which air was forced at a uniform rate.
- Method of particle size determination: no data
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data
TEST ATMOSPHERE
- Brief description of analytical method used: no data
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: no data
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): no data - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 1 - 8 h
- Concentrations:
- from 40 to 2300 ppm
- No. of animals per sex per dose:
- 6 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: at least 10 days after the exposure
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, histopathology - Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 795 ppm
- Based on:
- test mat.
- 95% CL:
- 218 - 978
- Exp. duration:
- 1 h
- Remarks on result:
- other: included 25 % loss of the test item
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 124 ppm
- Based on:
- test mat.
- 95% CL:
- 95 - 169
- Exp. duration:
- 4 h
- Remarks on result:
- other: included 25 % loss of the test item
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 57 ppm
- Based on:
- test mat.
- 95% CL:
- 50 - 65
- Exp. duration:
- 8 h
- Remarks on result:
- other: included 25 % loss of the test item
- Mortality:
- no data
- Clinical signs:
- other: Apearance of anxiety, lacrimation, tremors. Coma occasionally preceded the death and diarrhea before death.
- Body weight:
- no data
- Gross pathology:
- edema and congestion of the lungs (confirmed microscopically), visceral congestion, discolored livers, some with necrotic areas, swollen and discolored kidneys.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category I
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 of Allyl alcohol to rats was 124 ppm or 0.297 mg/L.
- Executive summary:
In the acute inhalation experiments, six male rats were exposed for one four or eight hours to concentrations ranging from 40 to 2300 ppm. The exposure to the test item was accompanied by an appearance of anxiety, lacrimation and tremors. Diarrhea occured before death and coma occasionally preceded the death. The common gross findings in rats that died were edema and congestion of the lungs (confirmed microscopically), visceral congestion and discolored livers, some with necrotic areas. The kidneys were swollen and discolored. The LC50 of 1, 4 and 8 hours were 795, 124 and 57 ppm respectively (included 25 % loss of allyl alcohol, as stated in the chemical analysis).
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