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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from handbooks and authoritative databases

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Patty's Industrial Hygiene and Toxicology- Phenetole
Author:
Frank Arthur Patty, George D Clayton, Florence E Clayton
Year:
1981
Bibliographic source:
Patty's Industrial Hygiene and Toxicology- Phenetole, 6th Edition, 2012
Reference Type:
review article or handbook
Title:
DOSE Doc. no.: P73
Author:
S.D Gangolli
Year:
1999
Bibliographic source:
The Dictionary of Substances and their Effects (DOSE), Edited by S D Gangolli, Second Edition, pg 204, 1999
Reference Type:
other: Authoritative data base
Title:
HSDB for the test material
Author:
US National Library of Medicine reviewed by SRC
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US National Library of Medicine reviewed by SRC, 2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of the test chemical
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenetole
EC Number:
203-139-7
EC Name:
Phenetole
Cas Number:
103-73-1
Molecular formula:
C8H10O
IUPAC Name:
ethoxybenzene
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Phenetole
- Molecular Formula: C8H10O
- Molecular Weight: 122.17 g/mol
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Phenetole
- Molecular Formula: C8H10O
- Molecular Weight: 122.17 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
Not available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
Not available
Duration of treatment / exposure:
Not available
Observation period:
Not available
Number of animals:
Not available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Signs of slight irritation were observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:

Administration of the test chemical to the rabbit resulted in a slight skin irritation effect which is not adequate for classification as a skin irritant. Therefore, it can be concluded that the test chemical was not irritating to skin.
Executive summary:

Administration of the test chemical to the rabbit resulted in a slight skin irritation effect which is not adequate for classification as a skin irritant. Therefore, it can be concluded that the test chemical was not irritating to skin.