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EC number: 251-908-0 | CAS number: 34274-28-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- Application of radiolabelled substance and observation of absorption and excretion in urine.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrilotrimethylenetris(phosphonic acid)
- EC Number:
- 229-146-5
- EC Name:
- Nitrilotrimethylenetris(phosphonic acid)
- Cas Number:
- 6419-19-8
- Molecular formula:
- C3H12NO9P3
- IUPAC Name:
- [nitrilotris(methylene)]tris(phosphonic acid)
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 male (bwt 208-222 g) and 5 female (171-215g) Wistar rats
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of exposure:
- 48 hours
- Doses:
- 200 µl (0.2 ml) of a 0.88% aqueous solution (pH 7) of 14C-ATMP (equivalent to 1.76 mg ATMP/ rat; 27.1 µCi/rat) was applied to 10 cm² area of shaved skin (24 hours prior to application) under occlusion for 48 hours.
Comment: based upon a mean body weight of 216.4 g for males and 186.4 g for females, this was equivalent to 8.1 or 9.4 mg/kg bw, respectively. - No. of animals per group:
- 5 male, 5 female
- Details on study design:
- PREPARATION OF DOSING SOLUTION
The test sample was prepared by custom synthesis 8.50 mg 14C-ATMP (540 µCi) was mixed with 26.0 mg unlabelled material and 3954 mg double distilled water. Comment: the final concentration of ATMP in the dosing solution appears to be 0.89% and not 0.88% as stated in the report.
Comment: It is not clear how the solution was neutralised to pH 7.0; use of NaOH may have resulted information of the sodium salt.
SAMPLE COLLECTION
Radioactivity present in urine, faeces, exhaled air (14C-carbon dioxide), skin (application site), carcass and cage wash was quantified over a 48 hours post-application period.
Results presented as mean and SD.
Results and discussion
- Absorption in different matrices:
- The majority of the dose remained at the application site 48 hours after application, with trace amounts excreted in urine, faeces and as 14C-carbon dioxide or remaining in the carcass:
- Urine: 0.2-0.5%
- Faeces: 0.087-0.03%
- CO2: 0.087-0.061%
- Skin (application site): 76.3-60.2%
- Carcass: 0.22-0.35% (Mean data for males or females, respectively) The total absorbed over 48 hours was 0.603% of the dose in males, and 0.940% of the dose in females.
Of the material absorbed:
- urinary excretion was virtually complete during the first 24 hours post-treatment (93-95% of total present in urine) with negligible excretion between 24-48 hours; - faecal elimination was comparable over 0-24 hr and 24-48 hours (approx. 50% of total excreted present at each time point);
- slightly more 14C-CO2 was exhaled over 0-8 hours (40-50% of total excreted) than over 8-24 hours or 24-48 hours.
Percutaneous absorptionopen allclose all
- Time point:
- 48 h
- Dose:
- 200 µl of a 0.88% aqueous solution (pH 7) of 14C-ATMP
- Parameter:
- percentage
- Remarks:
- male rats
- Absorption:
- 0.603 %
- Time point:
- 48 h
- Dose:
- 200 µl of a 0.88% aqueous solution (pH 7) of 14C-ATMP
- Parameter:
- percentage
- Remarks:
- female rats
- Absorption:
- 0.94 %
Any other information on results incl. tables
absorption: 0.603% (male); 0.94% (female)
excretion: the majority of the absorbed radiolabelled ATMP was excreted in the urine within 24 hours of treatment.
Applicant's summary and conclusion
- Conclusions:
- The cutaneous absorption of radiolabelled ATMP over 48 hours was 0.603% in male rats and 0.94% in females. 60-75% of the applied material was recovered from the application site at 48 hours. Absorbed. Radioactivity was excreted mainly in urine over the first 24 hours following application.
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