Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-816-9 | CAS number: 15721-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Physical state
Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is an off white powder at room temperature.
Melting / freezing point
Key study:
In a study conducted according to OECD Guideline 102 (not conducted to GLP), the melting point of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is 98.9℃ (Intertek, 2012).
Supporting study:
Using The Estimation Programs Interface (EPI) SuiteTM was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC), the melting point of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is determined as 165.16℃ (EPIWIN, 2012).
Boiling point
Key study:
In a study conducted according to OECD Guideline 103 (not conducted to GLP). no boiling point was observed within the instrument threshold of 400°C, therefore the boiling point of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is >400°C.
Supporting study:
Using The Estimation Programs Interface (EPI) SuiteTM was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC), the boiling point of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is determined as 431.62℃ (EPIWIN, 2012).
Relative density
In a study conducted according to OECD Guideline 109 (not conducted to GLP), the relative density of the bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is 0.98 at 20℃ (Intertek, 2012).
Granulometry
In a study conducted to OECD 110 (not conducted to GLP), the manual sieve analysis indicated that a negligible percentage by weight of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine has a particle size of >2,000 μm. A laser diffraction analysis showed that 10% of the substance has a particle size of <52.296 μm, 50% is <400.623 μm and 90% is <1135.736 μm (Intertek, 2012).
Vapour pressure
Key study:
In a study conducted according to EU Method A4 (not conducted to GLP), the vapour pressure of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine was determined as <1.1E-05 Pa at 20℃ and 25℃ (Intertek, 2012).
Supporting study:
Using The Estimation Programs Interface (EPI) SuiteTM was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC), the vapour pressure of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is determined as 0.00111 Pa at 25℃ (EPISUITE, 2012).
Partition coefficient n-octanol/water
Key study:
In an OECD 117 studay (not conducted according to GLP), the partition coefficient of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine was determined as 8.8 at 20℃ (Intertek, 2013).
Supporting study:
Using The Estimation Programs Interface (EPI) SuiteTM was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC), the partition coefficient of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is determined as 10.82 (EPISUITE, 2012).
Water solubility
Key study:
In a study conducted according to OECD Guideline 105 (not conducted to GLP), the water solubility of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is <0.1 mg/L at 25℃ (Intertek, 2012).
Supporting study:
Using The Estimation Programs Interface (EPI) SuiteTM was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC), the water solubility of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is determined as 9.72E-07 mg/L at 25℃(EPISUITE, 2012).
Surface tension
In a study conducted according to OECD Guideline 115 (not conducted to GLP), the surface tension of bis(4-(1,1,3,3 -tetramethylbutyl)phenyl)amine was determined as 71.4 mN/m at 25℃ (Intertek, 2012).
Flash point
A flash point study is applicable for liquid substances, while a flammability study is applicable for solids. Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is a solid, therefore the flammability study is more applicable for testing and the flash point study is waived.
Autoflammability / self-ignition temperature
In a study conducted according to EU Method A10 (not conducted to GLP), when the flame was applied to bis(4-(1,1,3,3 -tetramethylbutyl)phenyl)amine it melted. When the flame was applied to a liquid sample of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine it did not ignite within the four minute test period. The substance should not be considered as highly flammable and no further testing is required (Intertek, 2012).
Flammability
In a study conducted according to EU Method A10 (not conducted to GLP), when the flame was applied to bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine it melted. When the flame was applied to a liquid sample of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine it did not ignite within the four minute test period. The substance should not be considered as highly flammable and no further testing is required (Intertek, 2012).
Explosive properties
In a study conducted to EU Method A.14 (Explosive properties) (not conducted to GLP), the examination of the molecular formula (using Bretherick, L., Handbook of Reactive Chemical Hazards, 4th edition, Butterworths, London, ISBN 0-750-60103-5, 1990) of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine shows it does not present any risk of explosion (Intertek, 2012).
Oxidising properties
In a study conducted according to EU Method A.17 (not conducted to GLP), examination of the molecular formula of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine shows it does not contain any common oxidising agents and is not an oxidizing substance (Intertek, 2012).
Stability in organic solvents and identity of relevant degradation products
According to Column 1 of Annex IX of the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) legislation, stability in organic solvents and identity of relevant degradation products study does not need to be conducted if the substance stability is not considered critical. The stability of bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is not a concern, therefore this endpoint has been waived.
Dissociation constant
In a dissociation constant study conducted according to OECD Guideline 112 (not conducted according to GLP), the pKa value of Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine was predicted as 2±0.5 using the ACD/pKa DB software (Intertek, 2013).
Viscosity
Bis(4-(1,1,3,3-tetramethylbutyl)phenyl)amine is a solid (white odourless powder) at room temperature; therefore a viscosity study is not appropriate and this endpoint is waived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.