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Diss Factsheets
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EC number: 237-926-1 | CAS number: 14073-97-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.031 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.306 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.003 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 2 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.558 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.056 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.093 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 246.67 mg/kg food
- Assessment factor:
- 30
Additional information
L(E)C50 values for all three trophic levels are available. The PNEC aqua (freshwater) is derived from the EC50 value of 30.6 mg/L found in the acute aquatic toxicity study with freshwater invertebrates as the most sensitive species tested. The PNEC STP is derived from the non-inhibitory concentration of 20 mg/L applied in the toxicity control of the valid study on ready biodegradability. The PNEC sediment and PNEC soil have been derived by using the equilibrium-partitioning method. The PNEC oral is based on a NOAEL of 370 mg/kg bw/day derived from a chronic study with DL-menthol in rats.
Conclusion on classification
Available aquatic toxicity data:
The most sensitive aquatic species was Daphnia with an 48 -hour EC50 of 30.6 mg/L. The ErC50 value after 72 hours in a valid algal toxicity study with the L-menthan-3-one was 58 mg/L and the ErC10 value was 31 mg/L. No LC50 value was derived in the short-term fish toxicity study.
Acute aquatic toxicity classification:
Based on above stated L(E)C50 data, no classification for acute aquatic toxicity necessary according to both the CLP and the DSD Regulation.
Chronic aquatic toxicity classification - GHS:
Since the 2nd Amendment of the CLP Regulation, data from long.term studies (if ever available) are preferred over data from acute studies for chronic aquatic toxicity classification. The only available long-term study is the algal growth inhibition study, which revealed an EC10 of 31 mg/L, which does not trigger classification. The EC50 of 30.6 mg/L coming from the acute Daphnia study also does not trigger classification, as the substance is rapidly degradable and has a log Kow < 4.0.
Chronic aquatic toxicity classification - DSD:
In the DSD Regulation data from long-term studies had not yet been considered for chronic aquatic toxicity classification. Based on DSD Regulation 67/548/ECC, Annex VI, 5.2.1.2., a substances shall be classified as dangerous for the environment R52/53 if the L(E)50 is within the range 10 - 100 mg/L and the substance is not readily degradable. While the EC50 values for Daphnia and algae are within above stated concentration range, the substance on the other hand is considered as readily biodegradable, thus no classification is applicable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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