Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-556-4 | CAS number: 108-16-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- other: BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(dimethylamino)propan-2-ol
- EC Number:
- 203-556-4
- EC Name:
- 1-(dimethylamino)propan-2-ol
- Cas Number:
- 108-16-7
- Molecular formula:
- C5H13NO
- IUPAC Name:
- 1-(dimethylamino)propan-2-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Dimethyl-isopropanolamin
Test animals
- Species:
- mouse
- Strain:
- other: Hannover-mouse
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 0.1, 0.125, 0.16, 0.2, 0.4, 1.6 mL/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 150 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.18 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value
- Mortality:
- 0/10 animals died at 0.1 mL/kg bw
1/10 animals died at 0.125 mL/kg bw
4/10 animals died at 0.16 mL/kg bw
7/10 animals died at 0.2 mL/kg bw
9/10 animals died at 0.4 mL/kg bw
5/5 animals died at 1.6 mL/kg bw
deaths occured within day 1-8 - Clinical signs:
- Apathy, staggering, dyspnoea, slight spasms and late deaths
- Body weight:
- no data
- Gross pathology:
- Animals that died during the study: slight irritation at injection site
Animals that were sacrificed at the end of the study: no findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
