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EC number: 241-793-5 | CAS number: 17832-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The combined oral LD50 in male and female rats was 1740 mg/kg bw, in males 1780 mg/kg bw and for females 1540 mg/kg bw.
Inhalation of saturated vapour for 7 hrs in rats resulted in slight clinical signs but in no mortality in the inhalation hazard test.
In a limit test on acute dermal toxicity in rats no clinical signs were reported at a dose of 2000 mg/kg bw; LD50 is >2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 740 mg/kg bw
Additional information
Oral
In a study comparable to OECD 401 groups of 5 rats per sex and dose group were administered with 2150, 1780, 1470, 1000 and 464 mg/kg bw of the test substance. The acute LD50 of the test substance in rats was found to be 1740 mg/kg bw for male and female animals combined, the LD50 for males was 1780 mg/kg bw and for females 1540 mg/kg bw. Within 30 min after administration, dyspnoea, apathy, staggering gait, ruffled fur and poor general condition was observed in the lowest dose group; no signs were seen after 4 h. In the higher dose groups, dyspnoea, apathy, abnormal position, staggering gait, atony, loss of pain and corneal reflex, narcosis like condition, ruffled fur, cyanosis, dehydration and poor general condition was observed. No signs were observed 2 day after administration, except ruffled fur was noted in 1000 and 1470 mg/kg bw dose group till day three and 6, respectively. Substance caused congestion and hyperemia in animals that died, but necropsy revealed no effects in survivors (BASF 1984).
Inhalation
In a study comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) 6 rats (3 males and 3 females) were exposed for 7 hrs to a vapour saturated atmosphere (room temperature) at mean nominal concentration of 0.86 mg/L. No mortality was observed. Within 3 minutes after start of exposure and during the whole exposure period accelerated respiration was seen in 6/6 rats; 3 -30 minutes after start of exposure snout wiping was observed in 3 rats and 10 minutes after start trembling in 4 rats (not in later recordings). No clinical signs were detected after exposure and during the post exposure observation period of 14 days. No pathological changes were observed at necropsy (BASF 1988).
.
Dermal
In a limit test on acute dermal toxicity (comparable to OECD Guideline 402) 5 male and 5 female Wistar rats were exposed to 2000 mg/kg bw for 24 h (semi-occlusive); the post exposure observation period was 14 days. No clinical signs, no mortality, and no effects on body weight were recorded. Necropsy revealed no findings (BASF 1988).
Justification for classification or non-classification
Based on the available acute oral data, the substance is classified for acute toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 with cat. 4 (H302).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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