Registration Dossier
Registration Dossier
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EC number: 208-058-0 | CAS number: 506-87-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from a secondary source (publication) cited in a peer reviewed database.
Data source
Referenceopen allclose all
- Reference Type:
- other: peer reviewed database
- Title:
- Chemical Carcinogenesis Research Information System
- Author:
- CCRIS
- Year:
- 2 010
- Bibliographic source:
- http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CCRIS.htm search with CAS number 506-87-6 in 2010/10/08
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Diammonium carbonate
- EC Number:
- 208-058-0
- EC Name:
- Diammonium carbonate
- Cas Number:
- 506-87-6
- Molecular formula:
- CH2O3.2H3N
- IUPAC Name:
- diammonium carbonate
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 97
- Species / strain / cell type:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat, liver, S-9, Aroclor 1254
- Test concentrations with justification for top dose:
- 0.1-10 mg/plate
- Vehicle / solvent:
- test material solvent: water
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 97
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In the test conditions, Ammonium carbonate tested from 0.1 to 10 mg/plate in an Ames test on Salmonella typhimurium TA97 and TA102 gave negative results bot with and without metabolic activation.
Therefore, ammonium carbonate is not considered as genotoxic.
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