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EC number: 240-362-9 | CAS number: 16251-77-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October - November 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study in compliance with guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- other: Acute Oral Toxicity
- Limit test:
- yes
Test material
- Reference substance name:
- 3-phenylbutyraldehyde
- EC Number:
- 240-362-9
- EC Name:
- 3-phenylbutyraldehyde
- Cas Number:
- 16251-77-7
- Molecular formula:
- C10H12O
- IUPAC Name:
- 3-phenylbutanal
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): ST 25 C 88
- Physical state: clear liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited, Margate, Kent
- Age at study initiation: 4-7 weeks at arrival
- Weight at study initiation: ca. 160 g
- Fasting period before study: animals were fasted overnight prior to dosing
- Housing: animals were housed in single sex groups of five in grid bottomed polypropylene cages.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 11 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 12-27°C
- Humidity (%): 60 -68%
- Air changes (per hr): no data available
- Photoperiod (hrs dark / hrs light): Fluorescent lighting was controlled to give an artificial cycle of 12 hour light/12 hours dark per day.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Five male and five female animals were selected for treatment and weighed, the weight being used to calculate the amount of material to be administered at a dose volume of 10 ml/kg bodyweight. After dosing animals were returned to their cage and permitted access to food.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Five male and five female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: All animals were examined at approximately 30 minutes and 1, 2 and 4 hours after dosing and then daily for fourteen consecutive days.
- Frequency of observations and weighing: Any sign of toxicity or other effects were noted along with the time of onset and duration. Animals were weighed on Days 1, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: At the end of the fourteen day post dose observation period all animals were weighed and then sacrificed by carbon dioxide narcosis. All cadavers were subjected to gross examination including the opening of the thoracic and visceral cavities. The stomach and representative sections of the gastro-intestinal tract were examined. - Statistics:
- not applicable
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male was dead five seconds after dosing. Necropsy findings of pink frothy exudate in the trachea and pink inflated appearance of the lungs substantiated the view that this animal had been dosed into the lungs.
- Clinical signs:
- other: Hyperactivity was observed in the surviving males immediately after dosing together with hunched posture in two animals. All females exhibited hunched posture at this time. All animals exhibited hunched posture, piloerection and hypoactivity from 30 minut
- Gross pathology:
- Necropsy showed the following effects on animals.
In male animals, the findings included: white waxy plug in the urethra (2 of 4 males examined), white waxy plug in the bladder (1 of 4 males examined), minimal or moderate dilatation of the kidney pelvis (3 of 4 males examined).
In female animals, the findings included : fluid distension of the uterus (1 of 5 females), minimal dilatation of the kidney pelvis (1 of 5 females). - Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information under CLP REGULATION (EC) No 1272/2008 Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL
- Conclusions:
- It is concluded that the test material had little toxic effect when administered as a single oral dose of 2,000 mg/kg body weight.
- Executive summary:
A GLP-compliant acute oral toxicity study was conducted for the substance in rats at the limit dose of 2,000 mg/kg body weight. The study was conducted according to the OECD Testing Guideline No. 401. The substance was diluted in water prior to dosing at a volume of 10 mL/kg body weight. The single mortality occurred in a male animal and based on the necropsy evaluation was concluded to be due to a dosing error. Clinical signs were observed following dosing and consisted of indications of general malaise (piloerection, hunched posture), however all animals had fully recovered by Day 4 following dosing. All animals gained weight during the 2 -week observation period following dosing and no deaths occurred on study (other than the male that had received a dose into the lungs, causing mortality). Findings at necropsy were not indicative of significant toxicities in any organ. It was concluded that the substance had little toxicity when administered as a single oral dose at the limit dose, thus the LD50 is considered to be greater than 2,000 mg/kg body weight.
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