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EC number: 203-841-3 | CAS number: 111-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- At the start and end of exposure, 0.75 mL of test liquid was sampled from 1 test container of each test group, and after acetonitrile was equally added and stirred into this, it was analyzed using HPLC. The test material concentration of each test liquid was quantified from the ratio with the standard solution peak area to find the geometric mean.
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Japanese name: Oomijinko
- Source: Environment Agency, National Institute for Environmental Studies
- Age at study initiation: Male juvenile (born within 24 hours)
- Feeding during test: not fed during test
ACCLIMATION
- Acclimation period: rearing in conditioned water as used for test, prepared according to OECD Guideline 211; 1 organism/80 mL (25 organisms/2 L) or less
- Acclimation conditions: same
- Type and amount of food: Chlorella vulgaris (monocellular green algae)
- Feeding frequency: 0.2 mg C/organism/day
- Health during acclimation: Parent mortality rate 2 weeks prior to start of exposure: < 5% - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Approx. 250 mg/L (CaCO3 conversion)
- Test temperature:
- 20 +/- 1°C
- pH:
- The test liquid pH was not adjusted. During study: see table 3 . For test substance concentration 100 mg/L pH was only 5.1 and therewith outside the suitable range. This was thought to be due to the test material because the pH was low for a high concentration group at preparation.
- Dissolved oxygen:
- Saturated concentration of 60% or more
- Nominal and measured concentrations:
- Nominal concentrations: 0, 10, 18, 32, 56, 100 mg/L
Measured concentrations (geometric mean during 48h): 9.82, 17.3, 31.5, 55.0, 97.2 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: closed
- Material, size, headspace, fill volume: 100 mL glass beaker
- Aeration: no
- No. of organisms per vessel: 5 organisms/container
- No. of vessels per concentration (replicates): 4 containers/test group
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The conditioned water and Elendt M4 stated in OECD Chemical Test Guideline No.211 “Daphnia Magna
Reproduction Test” were used.
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod and light intensity: Indoor light, 16 hours lit (800 lux or less)
EFFECT PARAMETERS MEASURED: Immobility
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8
- Range finding study
- Test concentrations: 1, 10, 100 mg/L
- Results used to determine the conditions for the definitive study: yes - Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 97.2 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 73.1 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 64.3-83.2 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 55 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 31.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 97.2 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 97.2 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: none
Reference
Table 1: Measured Concentrations of the Test Substance in Test Water (Semi-Static Condition)
Nominal Concentration (mg/L) |
Measured concentration (mg/L) |
Geometric Mean During 48 Hours (mg/L) |
|||
0 Hour New |
Percent of Nominal |
48 Hours Old |
Percent of Nominal |
||
Control |
< 0.08 |
-- |
0.08 |
-- |
-- |
10.0 |
9.88 |
99 |
9.77 |
98 |
9.82 |
18.0 |
17.5 |
97 |
17.2 |
96 |
17.3 |
32.0 |
31.8 |
99 |
31.2 |
98 |
31.5 |
56.0 |
56.0 |
99 |
54.4 |
97 |
55.0 |
100 |
98.7 |
99 |
95.8 |
96 |
97.2 |
Table 2: The Number of Immobilised Daphnia magna (Percent Immobility)
Nominal Concentration (mg/L) |
MeanaMeasured Concentration (mg/L) |
Cumulative Number of Immobilized Daphnia (Percent Immobility) |
|
24 Hours |
48 Hours |
||
Control |
------ |
0 (0) |
0 (0) |
10.0 |
9.82 |
1 (5) |
1 (5) |
18.0 |
17.3 |
0 (0) |
1 (5) |
32.0 |
31.5 |
0 (0) |
0 (0) |
56.0 |
55.0 |
0 (0) |
2 (10) |
100 |
99.1 |
2 (10) |
18 (90) |
a: geometric mean
Table 3: pH Values
Nominal Concentration (mg/L) |
MeanaMeasured Concentration (mg/L) |
pH |
|
0 Hour New |
48 Hours Old |
||
Control |
--- |
8.4 |
8.1 |
10.0 |
9.82 |
8.3 |
7.8 |
18.0 |
17.3 |
7.3 |
7.2 |
32.0 |
31.5 |
6.7 |
6.8 |
56.0 |
55.0 |
6.2 |
6.3 |
100 |
97.2 |
5.1 |
5.0 |
a: geometric mean
new: freshly prepared test solutions
old: test solutions after 48 hours exposure
Table 4: Temperature
Nominal Concentration (mg/L) |
MeanaMeasured Concentration (mg/L) |
Temperature (°C) |
|
0 Hour New |
48 Hours Old |
||
Control |
--- |
19.9 |
20.0 |
10.0 |
9.82 |
19.9 |
20.0 |
18.0 |
17.3 |
19.9 |
19.9 |
32.0 |
31.5 |
20.0 |
19.9 |
56.0 |
55.0 |
20.0 |
19.9 |
100 |
97.2 |
20.0 |
19.9 |
a: geometric mean
New: freshly prepared test solutions
Old: test solutions after 48 hours exposure
Table 5: Dissolved Oxygen Concentrations
Nominal Concentration (mg/L) |
MeanaMeasured Concentration (mg/L) |
Dissolved Oxygen Concentration (mg/L) |
|
0 Hour New |
48 Hours Old |
||
Control |
--- |
8.8 |
8.5 |
10.0 |
9.82 |
8.8 |
8.5 |
18.0 |
17.3 |
8.8 |
8.5 |
32.0 |
31.5 |
8.8 |
8.5 |
56.0 |
55.0 |
8.8 |
8.7 |
100 |
97.2 |
8.8 |
8.7 |
a: geometric mean
New: freshly prepared test solutions
Old: test solutions after 48 hours exposure
Description of key information
The EC50 (48h) is 73.1 mg/L (geometric mean of measured concentrations).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 73.1 mg/L
Additional information
During the acute static immobilisation test with Daphnia magna according to OECD 202 90% of the daphnids were immobilised at the highest tested concentration of 100 mg/L (nominal). The EC50 was determined to be 73.1 mg/L (geometric mean of measured concentrations). Thus, the substance shows a toxicity to Daphnia magna under conditions tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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