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EC number: 284-851-5 | CAS number: 84988-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.049 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.49 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.005 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 15 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Sediment (marine water)
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 16.7 mg/kg food
- Assessment factor:
- 300
Additional information
No reliable toxicity data is avaiable for isononyl phospate. However, reliable toxicity data is available for the analogue, phosphoric acid, 2-ethylhexyl ester, and included in the dossier. The substance is not classified for the environment, but an algal inhibition study did show that the algae was affected by the presence of the test item over a 72 -hour exposure period. Therefore, PNECs have been derived where appropriate.
PNEC water:
PNECs have been derived based on the results of freshwater and marine algal inhibition studies. However, the PNECs derived should be treated with caution as the results come from studies conducted using Water Accommodated Fractions (WAFs).
WAFs may be used in cases where the test item is a complex mixture and is poorly soluble in water and in permitted auxiliary solvents and surfactants. Exposures to the test organisms are expressed in terms of the original concentration of test item in water at the start of the mixing period (loading rate) irrespective of the actual concentration of test item in the WAF.
Therefore, as the substance comprises two constituents of varying solubility (one constituent being of low solubility), it was considered appropriate to conduct the aquatic toxicity testing using WAFS
Given that toxicity cannot be attributed to a single component or a mixture of components but to the test item as a whole, results of the aquatic toxicity tested conducted, including the algal inhibition study, were based on nominal loading rates only.
It can be considered that from acute studies with the analogue, phosphoric acid, 2-ethylhexyl ester, conducting with WAFs, toxicity data is more likely to correspond to the toxicity of the more soluble component(s) i.e. 2-ethylhexyl dihydrogen phosphate. This component is not classified for the environment according to the C&L inventory on the ECHA website.
PNECs derived from studies conducted using WAFs should be viewed with caution according to the ECHA Guidance; Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance.
The nominal loading rates cannot be used to derive a PNEC, since partitioning in the environment will make the comparison with a PEC meaningless.
Therefore, the PNECs derived for water need to be treated which caution, as they may not reflect the substances individual constituents behaviour.
PNEC oral:
A PNEC oral has been derived. However, due to limited release of the substance to the environment and the lack of bioaccumulation potential of the substance, secondary poisoning is not anticipated to be of concern.
Conclusion on classification
The substance is not classified for the environment based on the results of acute toxicity testing studies conducted on fish, invertebrates, and algae, with representative species from both freshwater environments. The results of a ready biodegradation test and the substance physico-chemical properties, such as water solubility and partition coefficient, have also been taken into account.
The acute toxicity testing was conducted using Water Accomodated Fractions (WAF) of the test substance (see discussion sections of studies). Given that toxicity (if observed) cannot be attributed to a single component (or a mixture of components) but to the test item as a whole the results were based on nominal loading rates only, and are summarised below:
Acute toxicity to fish: The 96-Hour LL50 (lethal loading rate) based on nominal loading rates was greater than 100 mg/l loading rate WAF and correspondingly the No Observed Effect Loading rate was 100 mg/l loading rate WAF.
Acute toxicity to Daphnia magna: The 48-Hour EL50 (effective loading rate) for the test item to Daphnia magna based on nominal loading rates was greater than 100 mg/l loading rate WAF. The No Observed Effect Loading rate was 100 mg/l loading rate WAF.
Acute toxicity to Acartia tonsa: The 48-Hour LL50(lethal loading rate) based on nominal loading rates was 117.4 mg/L.
Acute toxicity to freshwater algae:
EL50(growth rate):49mg/l
No Observed Effect Loading Rate: 25 mg/l
The acute lethal loading level (expressed as the LL/EL50) is comparable to the LC/EC50 values determined for pure substances tested within their solubility range. They can therefore be used directly for classification.
Based on the results of the acute studies no lethal or sub-lethal effects were observed in fish or invertebrates magna at loading rates of 100 mg/l WAF.
For algae, the growth rate EL50 of 49 mg/l for freshwater species, is not sufficient for classification of the substance in Chronic Category 3 (for substances with a 72 hr ErC50 for algae of >10 to ≤100 mg/l), as the substance does not meet the other criteria required for Chronic Category 3 classification, which state the substance must also not be rapidly biodegradable and/or have an experimentally determined BCF≥500 (or log Pow≥ 4).
Therefore, the substance does not meet the criteria for classification for the environment.
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