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EC number: 261-619-1 | CAS number: 59130-69-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No adverse effects up to the limit of water solubility (< 0.05 mg/L) for Daphnia magna (OECD 211)
Key value for chemical safety assessment
Additional information
No studies investigating the long-term toxicity of Hexadecyl 2-ethylhexanoate (CAS No. 59130-69-7) to aquatic invertebrates are available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances C8-16-Fatty acid-2-ethylhexyl ester (CAS No. 135800-37-2) and 2-Ethylhexyloleat (CAS No. 26399-02-0) is conducted.
A read across from C8-16-Fatty acid-2-ethylhexyl ester (CAS No. 135800-37-2) and 2-Ethylhexyloleat (CAS No. 26399-02-0) to Hexadecyl 2-ethylhexanoate (CAS No. 59130-69-7) to cover the long-term toxicity to aquatic invertebrates endpoint is acceptable as first, all substances have common functional groups being fatty acid esters. The fact that the target substance is an ester of 2-ethylhexanoic acid and fatty alcohols with carbon chain lengths of C14 - C18 while the source substances are esters of 2-ethylhexanol and fatty acids with a carbon chain length of C8-C14 and C18, is not considered to invalid the read-across approach. This is assumed due to the similar physico-chemical properties and the common breakdown products of the substances, which are expected to be rapidly metabolised in the body via enzymatic hydrolysis to the starting materials (e.g., see Barron et al. 1999 for metabolism of esters in fish), which then fed into body’s natural catabolic processes, such as ß-oxidation and citric acid cycle (e.g., Rahn et al., 1973; Henderson, 1996).
All substances are measured or calculated to be insoluble in water and the main components of the substances have similar molecular weights of 368.6 g/mole (CAS No. 59130-69-7), 256.43 – 312.54 g/mole (CAS No. 135800-37-2) and 394.69 g/mole (CAS No. 26399-02-0). The volatility of all substances is low (< 0.0001 Pa at 20 °C). Hence, the behaviour, the fate, the bioaccumulation and thus the toxicity of the substances in the aquatic environment are considered to be identical.
The study with C8-16-Fatty acid-2-ethylhexyl ester (CAS No. 135800-37-2) was conducted under GLP according to OECD guideline 202, part II using Daphnia magna as test organism (Wierich, 1998). Test concentrations of 1 and 100 mg/L were applied as filtered test solutions. No effects on mortality and reproduction were observed in the 1 mg/L treatment. A significant reduction of reproduction was observed in the 100 mg/L treatment. The authors supposed that the effects in the 100 mg/L treatment was due to a better water soluble by-compound or, less likely, due to a toxic impurity. Hence, the 21d-NOEC is determined to be ≥ 1 mg/L.
The second study with 2-Ethylhexyloleat (CAS No. 26399-02-0) was also performed under GLP according to OECD guideline 202, part II using Daphnia magna as test organism (Kuech, 1995). Test concentrations of 1 and 100 mg/L were applied as filtered test solutions. Test concentrations were measured to be < 0.01 mg/L in both treatments. No effects on mortality and reproduction were observed in the 1 mg/L treatment. 90% mortality (on day 19) and 23% reduction of reproduction (day 21) was observed in the 100 mg/L treatment. The authors stated that the deaths in the higher concentration could be attributed to sample contamination. Hence, the 21d-NOEC is determined to be ≥ 1 mg/L.
Due to structural and property similarities to the read-across substances C8-16-Fatty acid-2-ethylhexyl ester (CAS No. 135800-37-2) and 2-Ethylhexyloleat (CAS No. 26399-02-0) these results also apply to Hexadecyl 2-ethylhexanoate (CAS No. 59130-69-7).
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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