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Diss Factsheets
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EC number: 204-909-5 | CAS number: 128-80-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Toxicokinetics assumption
- Type of information:
- other: Toxicokinetics assumption
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Toxicokinetik assumption
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Toxicokinetics assumption.
- GLP compliance:
- no
Test animals
- Species:
- other: Toxicokinetics assumption
- Strain:
- other: Toxicokineticsassumption
- Details on test animals or test system and environmental conditions:
- Toxicokinetics assumption.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- ABSORPTION:
The most imported physicochemical data (molecular weight, water solubility and logPow) determining the toxicokinetik behaviour (ADME) of the 6 members of the proposed anthraquinone category are all in the same range. The molecular weight of the six category members is between 418.487 and 534.644 g/mol. The water solubility is in general very low, and is in all category members < 0.02 mg/liter. The log Pow of all category members is >8 (range 8.2 and 10.7, experimental).
Each of the considered parameter alone indicates a low bioavailability. Taken all parameters together a toxicological relevant absorption is not assumed. - Details on distribution in tissues:
- DISTRIBUTION:
In general, the smaller the molecule, the wider the distribution. Based on the molecular weights of the group members, the distribution of the group members is limited. This assumption is supported by the very low water solubility and high log Pow which are not favourable for active transport or passive diffusion through body membranes
- Details on excretion:
- Excretion:
Metabolism is considered as not relevant, because no absorption is predicted. In case of a negligible absorption, due to the higher water solubility of the metabolites compared with their parent substances a rapid excretion is predicted. Therefore, bioaccumulation is not expected.
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- METABOLISM:
Metabolism is considered as not relevant, because no absorption is predicted. In case of a negligible absorption, no hydrolysis products are expected in toxicologically significant doses. There are no chemical structures or moieties which could be transformed by hydrolytical attack. It can be concluded that cleavage neither of the antraquinone group nor of the amino group will occur.
There are no experimental data available. In a QSAR evaluation (OECD Toolbox V 4.1) the predicted main phase I metabolic pathways are the oxidation of the alkyl side-chains and/or oxidation of the aromatic ring systems including an diimine formation. A reduction of the benzoquinone to the hydroxybenzoquinone is also possible (see Appendix 2; Reinblau RLW, CAS no. 41611-76-1 as example for the anthraquinone category).
All available mutagenicity assays are negative (in vitro tests with and without metabolic activation). This indicates that no genotoxic degradation products are produced.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.