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EC number: 221-259-8 | CAS number: 3048-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Available animal data indicate that VNB is an moderately irritating to rabbit skin, and is very slightly irritating to the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted 0.5 ml
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- Sites of application were inspected for signs of inflammation and injury at 1 hr and 1,2,3,7,and 10 days.
- Number of animals:
- 3 males, 3 females
- Details on study design:
- TEST SITE
- Area of exposure: dorsal trunk
- Type of wrap if used: gauze loosely covered with polythene sheeting.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no, but excess material removed with water moistened gauze.
- Time after start of exposure: 4 hr
SCORING SYSTEM: Erythema and edema were scored and recorded on a 5 point scale (0= no reaction, 4= severe reaction). - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hour observations
- Score:
- 1.46
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hour observations
- Score:
- 0.43
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritant / corrosive response data:
- There was marked erythema and edema at 1-2 days and thereafter slowly resolving, completely resolved by 10 days. Desquamation was observed in all animals from day 7. Necrosis was not seen.
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- VNB is a mild to moderate irritant to rabbit skin.
- Executive summary:
Ballantyne et al (1997) published results showing that the substance ethylidene norbornene is a mild to moderate irritant to rabbit skin (4 -hr occlusive exposure). All symptoms reversed within 10 days.
Reference
Inspection time after removed of wrap | Erythema score. Average (range) | Edema score. Average (range) |
1 hour | 0.7 (0 -1) | 1.2 (1 -2) |
1 day | 2.0 (1 -3) | 0.7 (0 -1) |
2 days | 1.2 (0 -2) | 0.3 (0 -1) |
3 days | 1.2 (0 -2) | 0.3 (0 -1) |
7 days | 0.2 (0 -1) | 0.3 (0 -1) |
10 days | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Comparable to guideline study. Well documented study which meets basic scientific principles.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Method not specified
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- A volume of 0.1 ml undiluted substance was applied to the conjunctival sac of one eye of each rabbit.
- Observation period (in vivo):
- Eyes were examined for signs of ocular and periocular inflammation and injury at 1, 4, and 24hr and 2,3,7 days postinstillation.
- Number of animals or in vitro replicates:
- 3 males, 3 females
- Details on study design:
- SCORING SYSTEM: Iritis and conjunctival irritation were scored according to Draize.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48, 72 hour observations
- Score:
- 0.53
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Max score seen 1
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48, 72 hour observations
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hour observations
- Score:
- 0.07
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritant / corrosive response data:
- Corneal effects were not observed and therefore not reported in the results above. Ther was slight conjunctival hyperemia, which began to resolve after 24 hr, was minimal by 2 days and all eyes normal by 7 days. A marked chemosis was at a maximum at 1-4 hr but quickly resolved. Mild transient iritis was seen but resolved within 24hrs.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information not classified Criteria used for interpretation of results: EU
- Conclusions:
- ENB is a slight transient irritant to the rabbit eye.
- Executive summary:
Ballantyne et al (1997) published results showing that vinyl norbornene is slightly irritating to the rabbit eye.
Reference
Mean and range of scores for eye irritation produced by ENB instilled in the rabbit eye. Range shown in brackets.
Observation time | Redness | Chemosis | Iritis | |
1 hr | 1.0 (all 1) | 1.2 (1 -3) | 0.3 (0 -1) | |
4 hr | 1.0 (all 1) | 1.0 (1 -2) | 0.2 (0 -1) | |
24 hr | 1.0 (all 1) | 0.2 (0 -1) | 0 | |
2 days | 0.3 (0 -1) | 0 | 0 | |
3 days | 0.1 (0 -1) | 0 | 0 | |
7 days | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Occluded contact with 0.5 ml of undiluted the substance vinyl norbornene for 4 hrs produced mild to moderate erythema and edema on rabbit skin, which resolved by 7 -10 days; necrosis was not seen. 0.1 ml of undiluted VNB instilled into the rabbit inferior conjunctival sac caused conjunctival hyperemia that significantly resolved by 48 h post-instillation and disappeared completely within 7 days.
Justification for selection of skin irritation / corrosion
endpoint:
Only study in dossier
Justification for selection of eye irritation endpoint:
Only study in dossier
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
SKIN: From the available data, the level of skin irritation as measured by erythema, the most severe effect is not sufficient to warrant classification as a skin irritant under directive 67/548. Individual animal data is not available to enable a definitive classification against the criteria in regulation 1272/2008. However, it is not conceivable that that the level of edema seen would be sufficient (max level 1) to warrant classification and unlikely that the erythema findings would be sufficient either (max level 2 on days 2 and 3 and range 2 -3 on day 1) so a classification of irritant under the CLP regulation does not seem warranted either. However, as a hydrocarbon, use of the risk phrases R66/EUH066 would seem appropriate.
EYE: Available evidence from a study using vinyl norbornene indicates that the level of eye irritation produced by VNB is not likely to be sufficient to warrant classification.
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