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EC number: 482-400-9 | CAS number: 138776-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 482-400-9
- EC Name:
- -
- Cas Number:
- 138776-88-2
- Molecular formula:
- C52H56O6P2
- IUPAC Name:
- 9-[(3,3',5,5'-tetra-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2,4,6,12,14-hexaene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- Single exposure without rinsing.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 (3 males and 3 females)
- Details on study design:
- Male or female New Zealand White rabbits are dosed with volumes of 0.1, 0.01 and 0.005 ml (liquid or solid). The dose is instilled into the lower conjunctival sac of one eye per animal or is placed directly on the eye. The eyelids are held together for one second. Six eyes are dosed per test volume. The eyes are scored by the attached system at one hour, approximately 4 hours, one day, 2 days, 3 days and 7 days after dosing. Additional readings are made, if necessary, at 14 and 21 days. Fluorescein (2%) staining is used to determine corneal injury before dosing and at readings after one day.
SCALE FOR SCORING OCULAR LESIONS
Cornea:
A. Opacity--degree of density (most dense area taken for reading)
No opacity------------------------------------------------------- 0
Scattered or diffuse area, iris details clearly visible---------- 1
Easily discernible translucent areas, iris details slightly obscured------------------------------------------- 2
Opalescent areas, iris details not visible, pupil size barely discernible------------------------------------------ 3
Opaque, iris invisible------------------------------------------- 4
B. Area of cornea involved
One-quarter or less, but not zero-------------------------------- 1
Greater than one-quarter, but less than half--------------------- 2
Greater than half, but less than three-quarter------------------- 3
Greater than three-quarter, up to whole area--------------------- 4
Iris:
A. Normal----------------------------------------------------------- 0
Folds above normal, congestion, swelling, circumcomeal injection (any or all), iris still reacting to light-------- 1
No reaction to light, hemorrhage, gross destruction-------------- 2
Conjunctivae :
A. Vessels normal--------------------------------------------------- 0
Vessels definitely injected above normal------------------------- 1
Diffuse, deep crimson red, individual vessels not readily discernible------------------------------------- 2
Diffuse beefy red-------------------------------------- 3
B. No chemosis------------------------------------------------------ 0
Any swelling above normal (includes nictitating membrane)-------- 1
Obvious swelling with partial eversion of lids------------------- 2
Swelling with lids about half closed----------------------------- 3
Swelling with lids about half closed to completely closed-------- 4
C. No discharge------------------------------- 0
Any amount of discharge different from normal-------------------- 1
Discharge with moistening of the lids and hairs adjacent to lids--------------------------------------- 2
Discharge with considerable moistening around the eyes----------- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- other: All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- other: All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- other: All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- other: All animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Other effects:
- No corneal injury in any of the 6 eyes, minor transient irititis in 3 eyes at 1 hour after application, minor transient conjunctival irritation in 6 from 50 mg at 1 and 4 hour time points. All healed by 24 hr.
Any other information on results incl. tables
See details of scores in Attachments
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Executive summary:
Instillation of 50 mg of sample (equivalent of 0.1 ml) into rabbit eyes resulted in no corneal injury in any of 6 animals. Iritis was apparent in 3 animals and minor conjunctival irritation developed in 6 rabbits. Substantial ocular discharge was evident in 3 animals. After 24 hours, all rabbit eyes exhibited a normal appearance.
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