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EC number: 269-505-3 | CAS number: 68259-02-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 21, 1992 to January 15, 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- yes
- Remarks:
- Deionised water instead of distilled water used for preparation of stock solution; preparation of the inoculum: higher sludge weight after the washing procedure (sludge concentration in the test according to the guidelines); 4 instead of 5 test conc
- Qualifier:
- according to guideline
- Guideline:
- other: EG Method L 113/118
- Principles of method if other than guideline:
- Guidelines followed
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- no
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- Activated sludge from ARA Pro Rheno Basel (communal sewage treatment plant).
Pretreated by washing 3 times with tap water and addition of synthetic sewage (one day before main test). - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- No data
- Hardness:
- No data
- Test temperature:
- 20.7 °C
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- No data
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- None
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Relevant effect levels: 3h IC50 = 12.5 mg/L - Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- yes
- Conclusions:
- 3 h IC50 to activated sludge was >320 mg/L.
- Executive summary:
A study was conducted to determine the toxicity of the test substance (of ca. 100% purity) to activated sludge according to OECD 209 and EG Method L 133/18.
Sludge from a domestic wastewater treatment plant was exposed for 3 h at 0, 10, 32, 100 and 320 mg/L. The reference substance 3 -5, dichlorophenol was also tested at 3.2, 10 and 32 mg/L.
Based on the findings of the study, the 3 h IC50 was >320 mg/L. The 3 h IC50 for the reference substance was 12.5 mg/L.
Reference
None
Description of key information
3-hour IC50 of FAT 40171/D to activated sludge micro-organisms was determined to be >320 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 320 mg/L
Additional information
The key study was performed to evaluate the inhibitory effect of the test item FAT 40171/D on the respiration rate of aerobic wastewater micro-organisms of activated sludge in a 3-hour respiration inhibition test according to the OECD Guideline for Testing of Chemicals, No. 209.
Thus, the 3-hour IC50 of FAT 40171 to activated sludge micro-organisms was determined to be >320 mg/L.
Several other studies performed between 1983 to 1993 reported 3-hour IC50 to be >320 mg/L.
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