Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 267-021-7 | CAS number: 67762-52-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The toxicity ofcarboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1) to terrestrial organisms was tested in one available long-term toxicity test on earthworms. Eisenia fetida was exposed to the substance in artificial soil according the specifications given in OECD guideline 222 under GLP conditions (Eisner, 2013). Nominal concentrations of 62.5, 125, 250, 500 and 1000 mg/kg dw were tested. The mortality and growth of adult earthworms was determined after 28 days. Another 28 days later the reproduction rate was assessed. Adverse effects of the substance were not observed and thus a NOEC (56 d) ≥ 1000 mg/kg was determined based on reproduction. Studies on other terrestrial organisms are not available but a toxicity of the substance to terrestrial organisms is considered to be unlikely.
The test substance is characterized by a log Koc > 5 indicating a high potential for adsorption to soil particles. Tests with soil-dwelling organisms that feed on soil particles are therefore most relevant for the evaluation of soil toxicity. In the absence of a clear indication of selective toxicity, an invertebrate (earthworm or collembolan) test is preferred, as outlined in ECHA guidance section R.7.11.5.3 (ECHA, 2012). Chronic soil macroorganism data are available resulting in no effects on reproduction for earthworms were observed (NOEC (56 d) ≥ 1000 mg/kg soil dw). Due to the low water solubility (< 0.05 mg/L), only low concentrations are expected in the pore water, which is the main exposure route for terrestrial plants.Since the pore water is the main route of uptake for terrestrial plants, the bioavailability of the substance is presumably low. An uptake of the substance by plant roots is also hindered by the high molecular weight of the substance (759 – 1095 g/mol) preventing the substance from crossing biological membranes. Therefore, tests with soil-dwelling organisms like earthworm which allows potential uptake via surface contact, soil particle ingestion and porewater (ECHA, 2012), are most relevant for the evaluation of terrestrial toxicity. In addition, in the absence of a clear indication of selective toxicity, an invertebrate (earthworm or collembolan) test is preferred, as outlined in ECHA guidance section R.7.11.5.3, page 122.
Moreover, carboxylic acids, C5-9, hexaesters with dipentaerythritol shows no inhibition to aquatic microorganisms in the read across with structurally similar analogue substances dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9) and isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol (CAS 84418-63-3). The applied test concentration is most likely in the range of concentrations that can be expected in the influent of a sewage treatment plant, as the substance has low water solubility (< 0.05 mg/L). The ECHA Guidance Document R.7c (ECHA, 2012) states that a test on soil microbial activity will only be additionally necessary for a valid PNEC derivation if inhibition of sewage sludge microbial activity has occurred. Therefore, toxicity to soil microorganisms is considered to be unlikely.
The available data are sufficient for an accurate hazard assessment of the terrestrial compartment. Based on all available data, further studies on the effects on terrestrial organisms do not have to be conducted since the chemical safety assessment indicates that toxicity to other terrestrial organisms in comparison to soil macroorganisms is not expected to be of concern.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.