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EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Two reliable guideline (OECD 207) studies on earthworms are available (Eisenia foetida), one performed with cloquintocet-mexyl (CGA185072 tech) (Rufli, 1989) and another with CGA153433 (metabolite of cloquintocet-mexyl). The endpoint selected for the chemical safety assessment is the LC50 of >1000 mg/kg reported by Rufli (1989).
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 1 000 mg/kg soil dw
Additional information
Rufli (1989) investigated the toxicity of cloquintocet-mexyl (CGA185072 tech) to earthworms (Eisenia foetida) in a GLP compliant study performed according to OECD 207. The highest number of mortalities was observed at the highest test concentration of 1000 mg/kg, where 5 out of 40 earthworms (13%) perished. Based on this, the 14-day LC50is greater than 1000 mg/kg dry weight soil (nominal concentration). The study was GLP compliant and is considered to be reliable without restriction.
An acute toxicity study of CGA153433 (metabolite of cloquintocet-mexyl) to the earthworm (Eisenia foetida) is also available (Kleiner 1999). The study was GLP compliant and performed according to OECD 207 with only minor deviation (Temperature deviation, not considered to have any impact on the test results). No effects were seen at the single nominal test concentration of 1000 mg test item/kg dry weight soil. Therefore the NOEC is determined to be 1000 mg test item/kg dry weight soil.
Both of the above studies are considered to be acute. The LC50 of >1000 mg/kg reported by Rufli (1989) for cloquintocet-mexyl has been selected for the chemical safety assessment.
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