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Diss Factsheets
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EC number: 217-617-8 | CAS number: 1912-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study design states it complies and it follows lates OECD guideline 404 (1981). Contains sufficient detail to suggest GLP-like characteristics even though no statement of certification is reported (reasonably thorough description of authors, dates, design, results, and interpretation).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Appraisal of the safety of chemicals in food, Drugs and Cosmetics by the staff of the division of pharmacology, FDA
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Draize (1959)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- version of May 1981
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Atrazine
- EC Number:
- 217-617-8
- EC Name:
- Atrazine
- Cas Number:
- 1912-24-9
- Molecular formula:
- C8H14ClN5
- IUPAC Name:
- 6-chloro-N2-ethyl-N4-(propan-2-yl)-1,3,5-triazine-2,4-diamine
- Details on test material:
- Atrazine technical
Appaerance: white powder
Supplier: OXON Italia S.p.A.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Six adult female white New Zealand were used for this procedure. They were 6 to 8 months old with body weights about 3.0 Kg. They were housed in individual cages at a laboratory standard diet for rabbits and were watered ad libitum. the room temperature was kept constantly at ca 18°C (max. limit), the relative atmospheric humidity 50 to 60%, and the daily illumination 12 hours.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 g of the substance to be tested were installed into one eye of each animal.
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- Ocular lesions were read 1h, 2h, 4h, 8h, 24h, 2d, 3d, 4d, 5d, 6d, 7d after the administration of the test substance
- Number of animals or in vitro replicates:
- 6 albino rabbit (white New Zealand) were used for the test.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1,#2,#3,#4,#5,#6
- Time point:
- other: 1h, 2, 4h, 8h, 24h, 2d, 3d, 4d, 5d, 6d, 7d
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Degree of opacity
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1,#2,#3,#4,#5,#6
- Time point:
- other: 1h,2h,4h,8h,24h,2d,3d,4d,5d,6d,7d
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Area of opacity
- Irritation parameter:
- iris score
- Basis:
- animal: #1,#2,#3,#4,#5,#6,#7
- Time point:
- other: 1h,2h,4h,8h,24h,2d,3d,4d,5d,6d,7d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1,#2,#3,#4,#5,#6
- Time point:
- other: 1h,2h,4h,8h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24h
- Remarks on result:
- other: Reddening of the palpebral conjunctiva
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1,#2,#3,#4,#5,#6
- Time point:
- other: 24h,2d,3d,4d,5d,6d
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Reddening of the palpebral conjunctiva.
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1,#3,#5#6
- Time point:
- other: 1h,2h,4h,8h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 1h,2h,4h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8h
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- other: 1h,2h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 4h
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1,#3,#5,#6
- Time point:
- other: 24h,2d,3d,4d,5d,6d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 8h,24h,2d,3d,4d,5d,6d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- other: 4h,8h,24h,2d,3d,4d,5d,6d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1,#2,#5
- Time point:
- other: 1h,2h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 4h
- Remarks on result:
- other: lachrymation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1,#2,#5
- Time point:
- other: 4h,8h,24h,2d,3d,4d,5d,6d
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: lachrymation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #3,#4,#6
- Time point:
- other: 1h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 2h
- Remarks on result:
- other: lachrymation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #3,#4,#6
- Time point:
- other: 2h,4h,8h,24h,2d,3d,4d,5d,6d
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: lachrymation
Any other information on results incl. tables
Summary of ocular lesions:
|
hours |
days |
|||||||||
Animal No. |
1 |
2 |
4 |
8 |
24 |
2 |
3 |
4 |
5 |
6 |
7 |
1 |
6 |
6 |
4 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
6 |
6 |
4 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
6 |
4 |
4 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
6 |
4 |
2 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5 |
6 |
6 |
4 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6 |
6 |
4 |
4 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
mean |
6 |
5 |
3.7 |
3.3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: ETAD SUBCOMMITTEE FOR TOXICOLOGY
- Conclusions:
- The substance Atrazine technical was treated undiluted (as powder) in a primary irritation test in rabbit eyes.
under the described conditions of the experiment it was found:
1. The conjunctival irritations of the first 12 hours disappeared after 24 hours.
2. according to the code of evaluation by ETAD SUBCOMMITTEE FOR TOXICOLOGY the substance is valuated as "non irritant"
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