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EC number: 265-512-0 | CAS number: 65140-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment. No Purity of test substance available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- Five male and female rats were dosed with 200, 500, and 1000 mg/kg bw, by intraperitoneal injection. The animals were observed for at least 14 days following administration, or until all symptoms had disappeared. Mortality was observed daily, a.m. and p.m. on working days. Signs and symptoms were observed daily, and body weight was determined on days 1, 7, 14 and at death. Necropsy of survivors was performed at the end of the observation period. Spontaneously dying animals were submitted to a gross necropsy as soon as possible.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Calcium diethyl bis[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate]
- EC Number:
- 265-512-0
- EC Name:
- Calcium diethyl bis[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate]
- Cas Number:
- 65140-91-2
- Molecular formula:
- C17 H29 O4 P. 1/2Ca
- IUPAC Name:
- calcium diethyl bis[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate]
- Details on test material:
- - Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Rat, Tif:RAIf(SPF), F3-crosses of RII 1/Tif X RII 2/Tif
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ciba-Geigy Ltd. Tierfarm, 4334 Sisseln, Switzerland
- Age at study initiation: 7-8 weeks
- Weight at study initiation: 185-259 g
- Fasting period before study: one night before treatment
- Housing: 5 per cage in Macrolon cages (Type 3)
- Diet: Rat food, NAFAG No. 890, NAFAG AG, Gossau, SG (Switzerland) was provided ad libitum.
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-3
- Humidity (%): ca. 55+/-15
- Air changes (per hr): ca. 15
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80
- Doses:
- 200, 500, and 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days or until all symptoms have disappeared
- Mortality observations: daily, a.m. and p.m. on working days
- Signs and symptoms: daily
- Body weight: on days 1, 7, 14 and at death
- Necropsy of survivors performed: yes, spontaneously dying animals were submitted to a gross necropsy as soon as possible; survivors at the end of the observation period. - Statistics:
- From the body weights, the group means and their standard deviations were calculated. When feasable, the LD50 including the 95% confidence limit were computed by the logit method (J. Berkson, J.Am. Stat. Ass. 39. 357-65, 1944).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 595 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 301 - 2 100
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 735 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 662 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 mg/kg bw: 0/5 (male), 0/5 (female)
500 mg/kg bw: 2/5 (male), 2/5 (female)
1000 mg/kg bw: 4/5 (male), 3/5 (female)
The animals died between 2-3 hours after administration of test substance. - Clinical signs:
- 200 mg/kg bw: Dyspnoea, exophthalmus, ruffled fur, and curved body position.
500 mg/kg bw: Dyspnoea, exophthalmus, ruffled fur, and curved body position.
1000 mg/kg bw: Dyspnoea, exophthalmus, ruffled fur, and lateral and curved body position.
The surviving animals recovered between 9 and 10 days after administration. - Body weight:
- For details see table 1 in "Any other information on results"
- Gross pathology:
- No gross lesions were found at necropsy.
Any other information on results incl. tables
Table 1: Mean body weight of male and female rats at day 1, 7, and 14.
Mean body weight (g) ± sd |
200 mg/kg bw |
500 mg/kg bw |
1000 mg/kg bw |
Day 1 male |
221±6.2 |
230±6.3 |
234±14.7 |
Day 1 female |
198±8.3 |
195±8.1 |
199±6.6 |
Day 7 male |
265±3.4 |
264±16.6 |
|
Day 7 female |
220±15.5 |
215V10.7 |
|
Day 14 male |
311±7.7 |
307±27.8 |
|
Day 14 female |
235±14.5 |
234±10.1 |
|
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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