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EC number: 202-680-6 | CAS number: 98-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is non-GLP and similar to OECD TG 426. It well documented, meets generally accepted scientific principles and is therefore acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- Method: Popliteal lymph node assay (PLNA)
- Principles of method if other than guideline:
- Method: Popliteal lymph node assay (PLNA)
- GLP compliance:
- not specified
- Type of study:
- other: Popliteal lymph node assay (PLNA)
Test material
- Reference substance name:
- p-menth-1-en-8-ol
- EC Number:
- 202-680-6
- EC Name:
- p-menth-1-en-8-ol
- Cas Number:
- 98-55-5
- Molecular formula:
- C10H18O
- IUPAC Name:
- 2-(4-methylcyclohex-3-en-1-yl)propan-2-ol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): alpha-terpineol
- CAS number: 98-55-5
- Source: Sigma Chemical (St. Louis MO, USA)
Constituent 1
In vivo test system
Test animals
- Species:
- other: rat
- Strain:
- other: Wistar
- Sex:
- female
Results and discussion
Any other information on results incl. tables
Table 1: Primary PLNA responses
Criteria |
Negative controls |
Vehicle |
Chlorpromazine |
||||
|
Terpineol |
Barbital |
DMSO |
Saline |
0.5 mg/paw |
2.5 mg/paw |
5.0 mg/paw |
N |
10 |
8 |
47 |
50 |
4 |
6 |
11 |
WI |
1.32 ± 0.71 |
1.06 ± 0.36 |
1.48 ± 0.65 |
1.12 ± 0.90 |
1.30 ± 0.35 |
2.06 ± 0.81* |
3.22 ± 1.13* |
CI |
2.00 ± 3.32 |
1.34 ± 0.92 |
2.95 ± 3.68 |
2.04 ± 2.03 |
1.26 ± 0.81 |
8.49 ± 8.91* |
8.28 ± 8.19* |
IPR, no. (%) |
2 (20) |
0 (0) |
5 (10.6) |
3 (6) |
0.0 |
50.0 |
63.6* |
* indicates that the value differs from that of the lowest dose group (0.5 mg/paw)
- Injected doses were 5 mg/paw (monoterpenes and barbital) or 50 µL /paw (vehicles).
- Values are means ± SD;
- Weight (WI) and Cellularity (CI) indices: values for the draining popliteal lymph node of the treated (right paw) side divided by that of the control (left paw) side.
- IPR, number (%) of rats within the group with WI ≥ 2 and CI ≥ 5.
- Substances were classified as negative because group mean values for WI and CI were lower than 2 and 5, respectively.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under these test conditions, alpha-terpineol was not considered as a sensitiser.
- Executive summary:
In a popliteal lymph node assay (PLNA), a group of 10 female Wistar rats were injected subcutaneously with alpha-Terpineol at 5 mg/paw into the right hind footpad while the contralateral footpad was injected with the vehicle (DMSO) alone. Chlorpromazine (CPZ) and barbital were used as positive and negative controls, respectively. Weight (WI) and cellularity (CI) indices for draining PLNs were determined 7 days after treatment.
Weight (WI) and cellularity (CI) indices for alpha-Terpineol was determined to be 1.32 ± 0.71 and 2.00 ± 3.32, respectively. Alpha-terpineol was classified as negative because group mean values for WI and CI were lower than 2 and 5, respectively.
Under these test conditions, alpha-terpineol was not considered as a sensitiser.
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