Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-446-6 | CAS number: 106-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no deviations from standard test guidelines and no methodological deficiences, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-bromopropene
- EC Number:
- 203-446-6
- EC Name:
- 3-bromopropene
- Cas Number:
- 106-95-6
- Molecular formula:
- C3H5Br
- IUPAC Name:
- 3-bromoprop-1-ene
- Reference substance name:
- 1-bromoprop-2-ene
- IUPAC Name:
- 1-bromoprop-2-ene
- Details on test material:
- Colourless liquid 99.2% purity
Storage at room temperature and in the dark
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- One control group and 3 test groups each of 5 male and 5 female rats.
The rats were selected so that males and females would be between 8 weeks and 12 weeks old on the day of exposure.
The rats were housed by sex in groups of 5 and acclimatisated to laboratory conditions for at least 5 days before the day of exposure.
The holding cages (size 35x53x25 cm) were made of stainless steel sheet and wire mesh and were suspended on a movable rack. While in their cages all rats had free access to a measured excess of food and tap water. Food and water supplies were analysed routinely to determine the levels of chemical or microbiological contaminants. Room lighting was by artificial light between 8 am to 8 pm daily.
The temperature and relative humidity of the hloding room air was monitired continuously. The temperature of the holding area during the study remained within the range of 21 °C ± 3°C and the relative humidity remained generally within the range 55% ± 15%. There were no extremes of temperature or humidity considered likely to have influenced the results of the study.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- Three groups of rats were exposed continuously for 4 hours to a test atmosphere containing the vapour of the test substance. Each group was exposed to a different concentration of vapour.
A further group acting as a control received clean air only for 4 hours. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Concentrations were :
Group 2 2.08 mg/L
Group 3 6.34 mg/L
Group 4 4.21 mg/L - No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- yes
- Details on study design:
- A supply of clean dried air was connected to the vapour generator and the supply pressure was adjusted to give a flow rate of 10 liters per minute measured at the generator outlet tube. An in-line flow meter was used to monitor air flow throughout the exposure.
A syringue filled with the test substance was fitted to the syringue pump and connected to the generator with PTFE tubing. A flow rate of 0.018 mL/minute was selected for the exposure of the first test group. This flow rate was expected to give a vapour concentration of approximatively 2 mg/L.
The rats to be exposed were placed into restraining tubes. The tubes were attached to the ports in the mid section of the chamber.
The syringue pump and air supply was switched on and the exposure timed for 4 hours, following a 7-minutes equilibration period.
Afetr 4 hours, the supply of test substance was discontinued and the exposure chamber was allowed to clear before the rats were removed for examination.
This procedure was repeated for groups 3 and 4 using flow rates of 0.055 mL/min and 0.039 mL/min respectively.
Following exposure, the rats were returned to the holding cages and food and water supplies were restored. The test rats were kept in a ventilated cabinet overnight and then returned to the holding room for the remainder of the observation period.
The control rats were returned to the holding room at the end of the exposure procedure.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2.41 mg/L air
- Based on:
- test mat.
- 95% CL:
- 1.805 - 3.022
- Exp. duration:
- 4 h
- Mortality:
- Group Level (mg/l) Mortality
M F Total
1 Control 0/5 0/5 0/10
2 2.08 1/5 2/5 3/10
3 6.34 5/5 5/5 10/10
4 4.21 5/5 5/5 10/10
One of the five males exposed to allyl bromide at 2.08 mg/L died on the day of exposure. Two of the five females exposed at this level were found dead at the early check on Day 1 of the observation period.
All male rats and 3/5 female rats exposed to allyl bromide at 6.34 mg/L died during the exposure. The 2 remaining females exposed at this level died shortly after exposure.
Two male and 2 female rats exposed at 4.21 mg/L died during exposure. Three male and 2 female rats exposed at this level died later on the day of exposure. The remaining female was found dead at the early check the following morning. - Clinical signs:
- other: During the exposure During exposure signs seen in rats exposed to allyl bromide were exaggerated respiratory movements and shallow breathing. Additional signs seen in rats exposed at 6.34 and 4.21 mg/L were restless behaviour and death. During the observ
- Body weight:
- In male rats surviving exposure to allyl bromide at 2.08 mg/L the rate of bodyweight gain for test rats was lower than that of the male control rats. The rate of body weight gain for female rats surviving exposure at this level was similar to that of the female control rats.
- Gross pathology:
- Slight to marked congestion of the lungs was found in all decedent rats exposed to allyl bromide. Dark or patchy congested areas on the lungs were seen in 1 male exposed at 2.08 mg/L, in 3 female rats exposed at 4.21 mg/L and 1 male and 1 female exposed at 6.34 mg/L. Areas of congestion were seen in rats exposed at 2.08 mg/L. The tracheas in decedent rats exposed at 4.21 mg/L were filled with a white frothy fluid. A dark appearance of the liver was seen in the majority of rats exposed at 6.34 mg/L.
Clear discharge from the snout was seen in the 2 decedent females exposed at 2.08 mg/L and yellow/brown staining was seen in one female rat exposed at 4.21 mg/L. Liquid in the mouth/nostrils was seen in decedent rats exposed at 4.21 mg/L.
There were no macroscopic abnormalities in surviving test rats and no abnormalities in the control rats.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Allyl bromide does require labelling with the hazard statement H331 Toxic if inhaled in accordance with the CLP regulation
- Executive summary:
In a GLP-compliant acute toxicity study conducted in accordance with standardised guideline OECD 403, the LD50 of the test material was calculated by exposing 5 males and 5 females Sprague-Dowley rats to three concentrations ranging from 2.08 to 6.34 mg/L via inhalation. Under the conditions of the test, mortality was observed even at the lower concentration. LD50 wa determined to be 2.41 mg/L of air.
Test material requires classification according to Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.