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EC number: 278-047-3
CAS number: 74993-03-6
The acute oral toxicity potential of the test article was
evaluated in male and female rats. The test was not intended to comply
with GLP guidelines. The test method was based on EEC Guidelines B.1
(1996) and OECD 423 (1996). Male and female rats (Wistar, 3/sex/group)
received 200 mg/kg test article suspended in bi-distilled water via
single oral gavage at a dose volume of 10 mL/kg. Three additional female
rats received 2,000 mg/kg test article in the same manner. Rats were
observed at 1, 2, 3 and 5 hours post-dose, and once daily for 14 days
for clinical signs of toxicity. Body weights were recorded on Day 1
(prior to administration) and on Days 8 and 15. All animals were
examined via necropsy at termination. All animals (3 females) dosed at
2,000 mg/kg were found dead 5 or 7 hours after treatment. Ruffled fur,
hunched posture, lateral recumbency, tremors and half closed lids were
noted in the female rats dosed at 2000 mg/kg prior to death. The animals
dosed at 200 mg/kg survived through the end of the observation period
and had no abnormal clinical signs. Black-brown contents in the stomach,
duodenum and jejunum were noted in all females dosed with 2000 mg/kg
test article upon necropsy. All other animals were without macroscopic
findings. The body weight gain of the animals in the 200 mg/kg group was
within the range commonly recorded for this strain and age. Based on the
results of the test, the oral LD50 of the test article is > 200 mg/kg
body weight (LD0) and < 2,000 mg/kg body weight (LD100).
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