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EC number: 246-904-0 | CAS number: 25371-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 72 hours
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- A volume of the test item (equivalent to 0.1 mL) was placed in the conjunctival sac of one eye in 6 New Zealand Albino Rabbits (6 ♀, approximately 9 weeks old) and the lid was held together briefly.
The ocular reactions of the cornea, iris, and conjunctiva were graded at 1, 2 and 3 days after dosing by the Draize scoring system. In addition, eyes were examined on day three using sodium fluorescein. - GLP compliance:
- yes
- Remarks:
- FDA's GLP
Test material
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Reference substance name:
- M-5925
- IUPAC Name:
- M-5925
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test Identification: M-5925
Description: White powder
Purity: Not reported
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Nicholas Helf
- Age at study initiation: 9 weeks
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing: Individually housed in suspended wire mesh cages
- Diet (e.g. ad libitum): Rabbits were fed Purina Rabbit Chow ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: approx. 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified (in accordance with the standards of AAALAC)
- Humidity (%): not specified (in accordance with the standards of AAALAC)
- Air changes (per hr): not specified (in accordance with the standards of AAALAC)
- Photoperiod (hrs dark / hrs light): not specified (in accordance with the standards of AAALAC)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye acts as a control
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 72h (the test item was not flushed from the eye after dosing)
- Observation period (in vivo):
- 72h
- Number of animals or in vitro replicates:
- 6 ♀, approximately 9 weeks old.
- Details on study design:
- The test item equivalent to 0.1 mL was placed in the conjunctival sac of one eye in 6 New Zealand Albino Rabbits (6 ♀, approximately 9 weeks old) and the lid was held together briefly.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
- Time after start of exposure: not applicable
SCORING SYSTEM: The ocular reactions of the cornea, iris, and conjunctiva were graded at 1, 2 and 3 days after dosing according to the method by Draize.
TOOL USED TO ASSESS SCORE: In addition, eyes were examined on day three using sodium fluorescein.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 h
- Score:
- 0.06
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 h
- Score:
- 1.39
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks:
- last evaluation was at 72 hr
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 0.89
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks:
- last evaluation was at 72 hr
- Irritant / corrosive response data:
- Based on the following mean scores for 24, 48 & 72 hours: Corneal opacity - 0, Iridial inflammation - 0.06, Conjunctival redness - 1.39,
Conjunctival chemosis - 0.89, the test item is not classified for irritation according to the criteria in Regulation (EC) 1272/2008. - Other effects:
- UV Fluorescein scan at 3 days was scored 0 in all animals.
Any other information on results incl. tables
Individual and mean scores for cornea, iris & conjunctivae for EC labelling regulations
Animal number |
Time after treatment |
Corneal opacity |
Iridial inflammation |
Conjunctival redness |
Conjunctival chemosis |
5001 |
24 hr |
0 |
0 |
2 |
1 |
48 hr |
0 |
0 |
1 |
1 |
|
72 hr |
0 |
0 |
1 |
0 |
|
Total |
|
0 |
0 |
4 |
2 |
Mean |
|
0 |
0 |
1.33 |
0.67 |
5002 |
24 hr |
0 |
1 |
2 |
2 |
48 hr |
0 |
0 |
2 |
2 |
|
72 hr |
0 |
0 |
1 |
2 |
|
Total |
|
0 |
1 |
5 |
6 |
Mean |
|
0 |
0.33 |
1.67 |
2.00 |
4352 |
24 hr |
0 |
0 |
2 |
1 |
48 hr |
0 |
0 |
1 |
1 |
|
72 hr |
0 |
0 |
1 |
0 |
|
Total |
|
0 |
0 |
4 |
2 |
Mean |
|
0 |
0 |
1.33 |
0.67 |
5006 |
24 hr |
0 |
0 |
2 |
1 |
48 hr |
0 |
0 |
1 |
1 |
|
72 hr |
0 |
0 |
1 |
1 |
|
Total |
|
0 |
0 |
4 |
1 |
Mean |
|
0 |
0 |
1.33 |
0.67 |
5007 |
24 hr |
0 |
0 |
2 |
1 |
48 hr |
0 |
0 |
1 |
1 |
|
72 hr |
0 |
0 |
1 |
1 |
|
Total |
|
0 |
0 |
4 |
3 |
Mean |
|
0 |
0 |
1.33 |
0.67 |
5008 |
24 hr |
0 |
0 |
2 |
1 |
48 hr |
0 |
0 |
1 |
1 |
|
72 hr |
0 |
0 |
1 |
1 |
|
Total |
|
0 |
0 |
4 |
3 |
Mean |
|
0 |
0 |
1.33 |
0.67 |
Group mean |
|
0 |
0.06 |
1.39 |
0.89 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- According to Regulation EC 1272/2008, dimethyl octadecylphosphonate is not classified as irritating to eyes.
- Executive summary:
The test item (equivalent to 0.1 mL) was placed in the conjunctival sac of one eye in 6 New Zealand Albino Rabbits (6 ♀, approximately 9 weeks old) and the lid was held together briefly. The ocular reactions of the cornea, iris, and conjunctiva were graded at 1, 2 and 3 days after dosing according to the grading system of Draize. In addition, eyes were examined on day three using sodium fluorescein.
Based on the following mean scores for all animals for 24, 48 & 72 hours: Corneal opacity - 0, Iridial inflammation - 0.06, Conjunctival redness - 1.39 and Conjunctival chemosis - 0.89, dimethyl octadecylphosphonate is not classified for irritation to the eye according to the criteria in Regulation (EC) 1272/2008.
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