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EC number: 700-651-7 | CAS number: 692-49-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
A GLP cardiac sensitization study was conducted using a titrated epinephrine challenge study design. A group of 6 male beagle dogs were exposed muzzle-only to vapours of the substance at concentrations of 12500, 25000, or 50000 ppm. Each level was evaluated in the animals with a minimum of 48 hours between each exposure and each dog served as its own control. Three days prior to exposure, a determination was made for the maximum level of epinephrine that would not cause a cardiac arrhythmia for each animal (sub-arrhythmia dose). The dogs were then exposed to the test compound for a total of approximately 33 minutes. After the first five minutes of exposure, each dog received a bolus intravenous injection of predetermined increasing doses of epinephrine up to and including the pre-determined maximum sub-arrhythmia dose. Epinephrine challenge bolus injections were administered a minimum frequency of 3 minutes apart or until the electrocardiogram (ECG) of the animal returned to its normal baseline rhythm. The dogs were monitored for the development of a cardiac arrhythmia. Cardiac arrhythmias were observed in 5 animals following exposure to 50000 ppm of the test substance and in 4 animals following exposure to 25000 ppm of the test substance. There were no signs of cardiac arrhythmia noted in animals that were exposed to 12500 ppm of the test substance. Under the conditions of this study, the no-observed adverse effect concentration (NOAEC) and lowest-observed adverse effect concentration (LOAEC) for cardiac sensitization in epinephrine-challenged dogs were 12500 ppm (83870 mg/m3) and 25000 ppm (1677740 mg/m3), respectively.
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