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EC number: 425-430-1 | CAS number: 6746-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral toxicity
Rat: LD50 (m/f) > 2000 mg/kg bw (EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure); DuPont Merck, 1997)
Acute Inhalation toxicity
Rat: LC50 (m/f) > 22.3 mg/l (OECD 403; DuPont Merck, 1997)
Acute Dermal toxicity
Rat: LD50 (m/f) > 2000 mg/kg bw (EU method B.3 Acute Toxicity (Dermal); DuPont Merck, 1997)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 22.3 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute Oral toxicity
The acute oral toxicity of the test substance was investigated in two groups of 5 male and 5 female rats, given doses of 500 and 2000 mg/kg bw as gavage. Signs of toxicity included piloerection, respiratory distress, hunched posture, waddling/unsteady gait and walking on toes all commonly seen in both males and females. Less often seen were; lethargy, pallid extremities, body tremors, thin appearance (both sexes) and blue/cold extremities, nasal discharge (red), soft to liquid feces, prostration, protruding eyes and ungroomed appearance (females only). One male and two females treated at 2000 mg/kg died during the study. Deaths occurred between three and a half hours and four days post dose.
Acute Inhalation toxicity
The acute inhalation toxicity of Ethynyl cyclopropane was assessed by exposing three groups of rats, each for a period of 4 hours, to a vapour produced from the test substance. During exposure, clinical signs of toxicity seen in rats exposed to Ethynyl cyclopropane at 22.3 mg/l included unsteady movement, occasional involuntary muscular contractions, unresponsiveness, piloerection, partial closing of the eyes and shallow respiration. Clinical signs seen in rats exposed to Ethynyl cyclopropane at 3.22 mg/l were partial closing of the eyes and a reduced
response to stimuli. There were no clinical signs during exposure to Ethynyl cyclopropane at 0.50 mg/l. Involuntary muscular contractions, staggering and hyperactivity were seen for up to 40 minutes post-exposure in rats exposed to Ethynyl cyclopropane at 22.3 mg/l. All rats exposed at this level were normal in appearance and behaviour within 40 minutes post-exposure. There were no clinical signs observed during the observation period in rats exposed to Ethynyl cyclopropane at 3.22 or 0.50 mg/l.
Acute Dermal toxicity
The acute dermal toxicity of the test substance was investigated in 5 male and 5 female rats. The test material was applied unchanged to the clipped epidermis of each animal at a limit dose level of 2000 mg/kg bw under semiocclusive conditions for 24 hours. No deaths and no systemic signs of systemic toxicity were noted for the limit dose. Reaction to treatment was confined to a localized (transient) dermal reaction at the treatment site involving very slight irritation (Grade 1 erythema with or without Grade 1 oedema). This response was first notable in eight animals following removal of the dressings, evident in smaller number of animals over the following days and resolving in all instances within five days of treatment. Bodyweight changes in the majority of animals were considered acceptable throughout for a study of this nature and duration. No abnormalities were observed at the study termination necropsy.
Justification for classification or non-classification
Acute Oral toxicity
Based on the criteria defined by the EU system, the test substance needs not to be labelled for acute oral toxicity, according to the criteria defined by the GHS system the test substance is classified to GHS Cat 5 because deaths occurred in the highest dosing group of 2000 mg/kg bw in male and female animals that could be attributed to the test substance administration.
Acute Inhalation toxicity
Based on the criteria defined by the EU and the GHS system, the test substance needs not to be labelled for acute inhalation toxicity, because no death occurred in the highest dosing group of 22.3 mg/l air in male and female animals that could be attributed to the test substance administration.
Acute Dermal toxicity
Based on the criteria defined by the EU and the GHS system, the test substance needs not to be labelled for acute dermal toxicity, because no death occurred in the highest dosing group of 2000 mg/kg bw in male and female animals that could be attributed to the test substance administration.
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