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EC number: 932-284-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Alchisor TAL 145 can be characterised according to three constituents: Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1-ol and dodecan-1-ol. The most sensitive endpoint for acute oral toxicity, reports an LD50 from studies with both dodecan-1-ol and tetradecan-1-ol of >2000mg/kg in the rat. The most reliable and relevant acute oral toxicity study (Holalagoudar, 2012), however, was conducted using Alchisor TAL 123 and also yielded an LD50 of >2000mg/kg. For acute inhalation toxicity the most sensitive endpoint is from a study with tetradecan-1-ol in rats, in which the LC50 was reported to be >1.5mg/l. In addition the most sensitive endpoint for acute dermal toxicity comes from a dodecan-1-ol study in the rabbit and reported a LD50 1500mg/kg - 2000mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 500 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
Additional information
Alchisor TAL 145 can be characterised according to three constituents: Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2 -25%), dodecan-1-ol and tetradecan-1-ol. As defined in the Read-Across Justification Document in section 13, data provided for these constituents when considered together is representative of Alchisor TAL 145 and suitable for assessment purposes. Study data for each constituent has been evaluated and considered together. The most reliable and relevant acute oral toxicity study (Holalagoudar, 2012), however, was conducted using Alchisor TAL 123 and yielded an LD50 of >2000mg/kg.
Oral
As detailed in Table 1 below 10 acute oral toxicity study reports are available for constituents of Alchisor TAL 145. Adequate reliable data is available for each constituent. Therefore, using our protective approach the dataset is a reliable adequate basis for Alchisor TAL 145 assessment purposes.
Table 1: Acute Oral Key/Supporting Studies for Constituents of Alchisor TAL 145
|
Constituents of Alchisor TAL 145
|
||
Reference |
Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) |
Dodecan-1-ol |
Tetradecan-1-ol |
Hempstock 1996a |
|
|
Key |
Scientific Associates 1977 |
|
|
Supporting |
Opdyke 1975 |
|
|
Supporting |
Cosmetic Ingredient Review |
|
|
Supporting |
IUCLID 2000 |
|
|
Supporting |
Exxon 1977 |
Key |
|
|
Hempstock 1996b |
|
Key |
|
Scientific Associates 1965 |
|
Supporting |
|
Henkel 1981 |
|
Supporting |
|
Lington 1994 |
|
Supporting |
|
The most sensitive study result identified across the constituents for acute oral toxicity has been reported in studies with dodecan-1-ol and tetradecan-1-ol. Both studies reported an LD50 of >2000mg/kg. In the first of the two studies, Kalcol 2098 (dodecan-1-ol) was assessed for acute oral toxicity in an OECD 401 guideline, GLP compliant study with SD rats. There were no deaths or clinical signs of toxicity and the LD50 was consequently determined to be >2000mg/kg (Hempstock 1996a). In the second study Kalcol 4098 (tetradecan-1-ol) was assessed for acute oral toxicity in an OECD 401 guideline, GLP compliant study with SD rats. There were no deaths and no signs of systemic toxicity during the study. The LD50 was consequently determined to be >2000mg/kg (Hempstock 1996b).
Studies evaluated for Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2 -25%) have reported endpoints that are less sensitive that the LD50 >2000mg/kg reported in the two acute oral studies documented above.
The most relevant and reliable study, however, is an OECD 423 acute toxicity, oral gavage study with Alchisor TAL 123 (Holalagoudar, 2012). The study, which was conducted using female Wistar rats, resulted in no animal deaths at a dose of 2000 mg/kg. Thus the median lethal dose of Alchisor TAL 123 after a single oral administration to female rats, observed over a period of 14 days, is LD50 > 2000 mg/kg. At a dose of 2000 mg/kg the study authors observed slight piloerection in all animals and other signs of toxicity in three of the six animals (slightly reduced spontaneous activity, half eyelid-closure).
In light of the study results presented here, Alchisor TAL 145 is determined to have an acute oral LD50 >2000mg/kg.
Inhalation
As detailed in Table 2 below, 8 acute inhalation toxicity study reports are available for constituent/constituent categories of Alchisor TAL 145. Adequate reliable data is available for each constituent/constituent category. Therefore, using our protective approach the dataset is a reliable adequate basis for Alchisor TAL 145 assessment purposes.
Table 2: Acute Inhalation Key/Supporting Studies for Constituents of Alchisor TAL 145
|
Constituents of Alchisor TAL 145
|
||
Reference |
Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2 -25%) |
Dodecan-1-ol |
Tetradecan-1-ol |
Scientific Associates 1977 |
|
|
Key |
Smyth 1969 |
|
|
Supporting |
Cosmetic Ingredient Review 1988 |
|
|
Supporting |
Hobert 1990 |
Supporting |
|
|
Coombs 1977 |
Key |
|
|
Amouruso 2008 & Carpenter 1975 |
Key (read across) |
|
|
Scientific Associates 1977 |
|
Key (read across) |
|
Clayton & Clayton 1994 |
|
Supporting |
|
The most sensitive reliable study identified across the 3 constituent/constituent categories for acute inhalation toxicity has been reported in a study with tetradecan-1-ol. In this reliable (Klimisch 2) study COX-SD rats were exposed to 1.5 mg/l test atmospheres of tetradecan-1-ol for 1 hour. No deaths were reported and there were no clinical signs of toxicity present at any point during the study. In this study the LC50 was determined to be >1.5mg/l (Scientific Associates Inc.1977[o1] ).
Reliable studies evaluated for both Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) and dodecan-1-ol have reported endpoints that are less sensitive. As a consequence of this study information Alchisor TAL 145 is determined to have an acute inhalation LC50 >1.5mg/l.
Dermal
As detailed in Table 3 below, 7 acute dermal studies are available for constituent/constituent categories of Alchisor TAL 145. Adequate reliable data is available for each constituent/constituent category. Therefore, using our protective approach the dataset is a reliable adequate basis for Alchisor TAL 145 assessment purposes.
Table 3: Acute Dermal Key/Supporting Studies for Constituents of Alchisor TAL 145
|
Constituents of Alchisor TAL 145
|
||
Reference |
Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2 -25%) |
Dodecan-1-ol |
Tetradecan-1-ol |
Scientific Associates 1977a |
|
|
Key |
Smyth 1969 |
|
|
Supporting |
Opdyke 1975 |
|
|
Supporting |
Coombs 1977 |
Key |
|
|
Scientific Associates 1975 |
|
Key |
|
Scientific Associates 1977b |
|
Supporting |
|
Lington & Bevan 1994 |
|
Supporting |
|
The most sensitive study identified across the 3 constituents for acute dermal toxicity has been reported in a study with dodecan-1-ol. This semi-occlusive acute dermal toxicity study was conducted with Alfol 12 alcohol (dodecan-1-ol) in NZW rabbits with an exposure time of 24hr. None of the animals survived application at the top dose (2g/kg), whereas there was only one death from a group of four animals at the 1.5g/kg dose level. Consequently the LD50 was reported as 1500mg/kg - 2000mg/kg (Scientific Associates Inc 1975).
Studies evaluated for both Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) and tetradecan-1-ol have reported endpoints that are less sensitive. As a consequence of this study information Alchisor TAL 145 is determined to have an acute dermal LD50 of 1500mg/kg - 2000mg/kg.
Justification for classification or non-classification
Alchisor TAL 145 based on the available acute toxicity information does not present an acute oral toxicity hazard since it is non-classifiable according Regulation (EC) No 1272/2008
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