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EC number: 610-150-4 | CAS number: 438193-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1171067-76-7
- Cas Number:
- 1171067-76-7
- IUPAC Name:
- 1171067-76-7
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- To determine the stability of the test item during the test period the concentrations were measured at test start, at 24 hours and at the end of
exposure.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- In order to get a saturated solution a surplus of the test item was dispersed in test water (100 mg/l) and stirred for 24 hours. The solid particles
were separated by filtration and the clear solution was used for the test. Separate formulations were prepared for each concentration Ievel by dilutingthe saturated solution of the test item with test water. On the basis of a 1 : 10 dilution the further concentrations were arranged in a geometric
series with the separation factor 1.6. The dilution steps covered a concentration range from 0.6 to 7.3 mg/l (table 1). For test group 5 no analytical
result at test start was available. Therefore the value was estimated by means of the separation factor and the data at 24 and 48 hours.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test animal was the water flea species Daphnia magna. Daphnia magna is recommended by the guidelines as a representative test organism for
aquatic invertebrates. They were bred within the laboratory by parthenogenesis and the individuals used were between 6 and 24 hours old.
Breeding conditions:
Light: 15 hours light, 9 hours dark
Feeding: at least 6 days per week with alga and yeast
Test water: aerated reconstituted water
Aeration: none
Temperature: 18.0 - 20.0°C
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- c (Ca++)= 2.04 mmol/L
c (Mg++)= 0.50 mmol/L
CaC03 = 254 ppm - Test temperature:
- 18.7 - 18.9°C
- pH:
- 8.0 - 8.1
- Dissolved oxygen:
- 8.9 - 9.0 mg O2/L
- Nominal and measured concentrations:
- measured 0.6, 1.1, 2.0, 2.9, 4.0 and 7.3 mg/L
- Details on test conditions:
- Duration: 48 hours
Procedure: static test, the test medium remained unchanged throughout the duration of the test.
Light: 15 hours light, 9 hours dark
Feeding: no feeding during the test period
Test water: aerated reconstituted water
c (Ca++)= 2.04 mmol/L
c (Mg++)= 0.50 mmol/L
CaC03 = 254 ppm
Oxygen concentration: at least 8.9 mg/l, the test vessels were not aerated. - Reference substance (positive control):
- yes
- Remarks:
- potassium chromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 0.6 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.5 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 2.9 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - The mortality in the control did not exceed 10 per cent at the end of the test.
- The dissolved oxygen concentration was at least 8. 9 mg/l.
- The concentration of the test item did not change during the test period. - Results with reference substance (positive control):
- EC50 (24 hours) = 1.7 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 h EC50 was determined to be 1.5 mg/L.
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