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EC number: 606-740-6 | CAS number: 21331-43-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study test phase 2012-05-23 to 2012-06-27. Study report date 2012-08-29.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Report on substance meets the criteria for classification as reliable without restriction to Klimisch et al (1997).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-(naphthalen-2-yl)-1,3-thiazol-2-amine
- EC Number:
- 606-740-6
- Cas Number:
- 21331-43-1
- Molecular formula:
- C13H10N2S
- IUPAC Name:
- 4-(naphthalen-2-yl)-1,3-thiazol-2-amine
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge from Totnes Sewage Works, Totnes, Devon, UK.
- Storage conditions: Aerated at room temperature and pH 7.0 +/-1.0
- Preparation of inoculum for exposure: Seven days prior to exposure the activated sludge was centrifuged, washed and resuspended in the mineral medium. The sludge was diluted in medium, added to test bottles and stirred until required for use. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 32 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22+/-0 deg. C
- pH: 7.4 +/-0.2
- pH adjusted: adjusted as necessary
TEST SYSTEM
- Measuring equipment: Oxitop respirometer
- Test performed in open system: no
- Details of trap for CO2: KOH placed in a sealed cup in the neck of the test bottles
SAMPLING
- Sample storage before analysis: ambient temperature
CONTROL AND BLANK SYSTEM
- Inoculum blank: Inoculum blanks containing no test or reference substance were used to deomnstrate there was no other carbon source in the medium
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 5 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 10 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 15 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 20 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- The reference substance attained a maximum mean level of biodegradation (based on BOD:ThOD ratio) of 67%. More than 60% biodegradation was acheived within the 10 day window.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- It is concluded that in this study the test substance failed to meet the criteria for ready biodegradability.
- Executive summary:
Introduction
This study was undertaken to determine the Ready Biodegradability of the test substance by measurement of biochemical oxygen demand (BOD) in a manometric respirometry test.
Results
The test material attained a maximum mean level of biodegradation of <5% during this study.
Conclusion
It is concluded that in this study the test substance failed to meet the criteria for ready biodegradability.
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