Registration Dossier
Registration Dossier
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EC number: 277-429-7 | CAS number: 73398-29-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 August 2018 to 09 August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- > 10 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 907 mg/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- >= 9.2 - <= 9.3
- Conclusions:
- Under the conditions of this study, the water solubility of the test material was > 10 g/L at 20 °C.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions.
The water solubility was determined using the flask method with HPLC analysis.
The water solubility of test material was determined as > 10 g/L because the measured concentration of test material was more than 10 g/L.
Under the conditions of this study, the water solubility of the test material was > 10 g/L at 20 °C.
Reference
Calculation of water solubility
- The water solubility of test material was determined as > 10 g/L because the measured concentration of test material was more than 10 g/L.
Table 1: Results
Sample |
pH |
Concentration of Test Material in Test Solution (g/L) |
||
Measured Value |
Average |
Standard Deviation |
||
A |
9.3 |
13.8 |
13.7 |
0.0882 |
B |
9.2 |
13.6 |
||
C |
9.2 |
13.7 |
||
Description of key information
Under the conditions of the study, the water solubility of the test material was > 10 g/L at 20 °C.
Key value for chemical safety assessment
Additional information
The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The water solubility was determined using the flask method with HPLC analysis.
The water solubility of test material was determined as > 10 g/L because the measured concentration of test material was more than 10 g/L.
Under the conditions of the study, the water solubility of the test material was > 10 g/L at 20 °C.
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