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EC number: 249-282-9 | CAS number: 28880-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Diisooctyl succinate
- EC Number:
- 249-282-9
- EC Name:
- Diisooctyl succinate
- Cas Number:
- 28880-24-2
- Molecular formula:
- C20H38O4
- IUPAC Name:
- bis(6-methylheptyl) succinate
- Test material form:
- liquid
Constituent 1
Test organisms
- Test organisms (species):
- Anabaena sp.
- Details on test organisms:
- Organism: The fresh water algal strain “Anabaena sp.” was used for this study. Commercially available media for blue-green algae BG-11 was used at concentration of 1.64 gm in 1 litre demineralized Water.
Study design
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 21–24°C controlled at ± 2 °C
- pH:
- 8.2 ± 1.5
- Details on test conditions:
- Illumination : 2960- 4440 lux
Growth medium : BG-11 Medium
Apparatus to determine algal biomass : UV-Vis Spectrophotometer
No. of replicates : Five in control and three in test groups - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC20
- Effect conc.:
- 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the condition of this test, it was concluded that maximum concentration of ‘Dicapryl Succinate’ at 0.1 mg/l elicited no inhibitory effects on the yield and specific growth rate of algae strain ‘Anabaena sp.’. Therefore the effective concentrations (ECs) and no observed effect concentration (NOEC) came out as:
EC10 : 1.3 mg/l
EC20 : 2.7 mg/l
EC50 : 6.7 mg/l
NOEC : 0.1 mg/l
The study was conducted as per the procedure described in the OECD Guideline for the testing of Chemicals, Freshwater Algae and Cyanobacteria, Growth Inhibition Test Guideline No. 201 Adopted on 28th July 2011. - Executive summary:
The study was conducted to determine the growth inhibition effect of ‘Dicapryl Succinate’on algae strain ‘Anabaena sp.’
A range finding study was conducted at four concentrations 1 mg/l, 10 mg/l, 50 mg/l & 100 mg/l of test item. Significant growth inhibitions were found at these concentrations.
Therefore, on the basis of range finding study, main study was conducted using concentration of 0.1, 0.5, 1, 5 and 10 mg/l in BG-11 medium.
The temperature was maintained within the range of 23.6-24.1°C and light intensity within the range of 4252-4265 Lux throughout the experimentation.
Under the condition of this test, it was concluded that ‘Dicapryl Succinate’ elicited no inhibition effects at 0.1 mg/l on the yield and specific growth rate of algae strain ‘Anabaena sp’. Therefore, the Effective concentrations (ECs) and No observed effect concentration (NOEC) came out as:
EC10 : 1.3 mg/l
EC20 : 2.7 mg/l
EC50 : 6.7 mg/l
NOEC : 0.1 mg/l
This study was hence, performed to assess the ‘Freshwater Algae and Cyanobacteria, Growth Inhibition Test By “Dicapryl Succinate”
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