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EC number: 240-898-3 | CAS number: 16872-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
An 48-h EC50 value of 100 mg/L HBF4 is used for assessment.
Key value for chemical safety assessment
Additional information
A GLP-compliant OECD 202 guideline study is available for toxicity in aquatic invertebrates (Daphnia magna) for the HBF4 structural analogue KBF4. In this combined limit/range-finding test 20 daphnids per concentration (4 vessels, 5 daphnia per vessel) were exposed to a control and a nominal KBF4 concentration of 100 mg/L in the limit test. In the range finding test 10 daphnids per concentration (2 vessels, 5 per vessel) were exposed to concentrations of 0.10, 1.0 and 10 mg/L. At the start and the end of the 48-hour test period, the nominal concentration of 100 mg/L from the limit test was analytically verified. At t=0 and t=48, measured concentrations were determined at 92 and 86% relative to nominal, respectively. Therefore, the test substance was considered to be stable throughout the test and all results were based on nominal concentrations. No significant effects on mobility of daphnids was observed in any of the concentrations tested. The 48-h EC50 value was >100 mg/L which, after correction for molecular weight, is equivalent to a 48 -h EC50 of >70 mg/L HBF4. However, as in this study no effects were seen at any of the concentrations tested and furthermore in the additional test with the HBF4 structural analogue NaBF4 much higher effects concentrations were observed (see below), his molecular weight correction is considered unproportional for purposes of risk assessment and classification and labeling. Therefore, the critical effect value of HBF4 for aquatic invertebrates is maintained at 100 mg/L.
In addition, a study on the short-term toxicity to aquatic invertebrates was performed with the HBF4 chemical analogue NaBF4. In this study, Daphnia magna were exposed to NaBF4 concentrations ranging from 1 to 10000 mg/L for 48 hours under static conditions. The number of living and dead neonates was noted at 24 and 48 h after the initiation of each trial. Neonates observed as motionless and without a discernable heartbeat were considered to be dead. Based on the immobilisation findings, the 48-h EC50 was determined at 4766 mg/L. When corrected for molecular weight, the 48-h EC50 for HBF4 is 3811 mg/L.
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