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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Description of key information

Read-across from soluble cobalt substances (i.e., cobalt dichloride and cobalt sulfate) and sodium sulfamate to cobalt(2 +) disulfamate is performed. A detailed documentation on read-across is attached on IUCLID section 13 (CoSulf_Read Across Assessment Framework Report).

Sodium sulfamate:

Based on the findings in an adjuvant sensitisation test (M&K-test) in guinea pigs and in accordance to Regulation (EC) No 1272/2008, Sodium Sulphamate, does not possess a skin sensitisation potential.

Soluble cobalt substances *:

Cobalt dichloride and cobalt sulfate were identified as skin sensitisers in animal studies (guinea pig maximisation test and adjuvant and patch test, respectively) and cobalt dichloride was identified as a skin sensitiser in human observations (largely studies with volunteers).

Reference: * SIAR, 2014: https://hpvchemicals.oecd.org/ui/handler.axd?id=b789fd1c-bab3-433c-9f47-3cbd49042976

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

For soluble cobalt substances studies in humans are available which are included in IUCLID secion 7.10.4 and discussed in endpoint summary IUCLID section 7.4 "Co_Sensitisation".

Justification for classification or non-classification

Cobalt chloride is already legally classified as skin sensitiser according to annex VI of regulation (EC) 1272/2008. This has been confirmed in animal tests and human case reports. Since, read-across to cobalt(2 +) disulfamate is considered to be fully justified cobalt(2 +) disulfamate will be classified as skin sensitiser category 1A (H317). Thus, further testing is not required, according to section 1.1.3 and 1.2, annex XI of regulation (EC) 1907/2006.

Since cobalt(2 +) disulfamate is produced and marked as 50% solution and the vapour pressure of this solution and cobalt(2 +) disulfamate tetrahydrate (only stable as tetrahydrate; see IUCLID section 4.6 "vapour pressure") is negligible and therefore, inhalation of cobalt(2 +) sulfamate is considered to be of low relevance, it is foreseen to not classify cobalt(2 +) disulfamate as respiratory sensitiser.